Innate receptors modulating adaptive T cell responses: KIR-HLA interactions and T cell-mediated control of chronic viral infections

Killer-cell immunoglobulin-like receptors (KIRs) are mainly expressed on natural killer (NK) cells and are key regulators of innate immune responses. NK cells are the first responders in the face of infection and help promote placentation during pregnancy; the importance of KIRs in these NK-mediated...

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Autores principales: Mora-Bitria, Laura, Asquith, Becca
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9887252/
https://www.ncbi.nlm.nih.gov/pubmed/36719466
http://dx.doi.org/10.1007/s00251-023-01293-w
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author Mora-Bitria, Laura
Asquith, Becca
author_facet Mora-Bitria, Laura
Asquith, Becca
author_sort Mora-Bitria, Laura
collection PubMed
description Killer-cell immunoglobulin-like receptors (KIRs) are mainly expressed on natural killer (NK) cells and are key regulators of innate immune responses. NK cells are the first responders in the face of infection and help promote placentation during pregnancy; the importance of KIRs in these NK-mediated processes is well-established. However, mounting evidence suggests that KIRs also have a prominent and long-lasting effect on the adaptive immune system. Here, we review the evidence for the impact of KIRs on T cell responses with a focus on the clinical significance of this interaction. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00251-023-01293-w.
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spelling pubmed-98872522023-01-31 Innate receptors modulating adaptive T cell responses: KIR-HLA interactions and T cell-mediated control of chronic viral infections Mora-Bitria, Laura Asquith, Becca Immunogenetics Review Killer-cell immunoglobulin-like receptors (KIRs) are mainly expressed on natural killer (NK) cells and are key regulators of innate immune responses. NK cells are the first responders in the face of infection and help promote placentation during pregnancy; the importance of KIRs in these NK-mediated processes is well-established. However, mounting evidence suggests that KIRs also have a prominent and long-lasting effect on the adaptive immune system. Here, we review the evidence for the impact of KIRs on T cell responses with a focus on the clinical significance of this interaction. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00251-023-01293-w. Springer Berlin Heidelberg 2023-01-31 2023 /pmc/articles/PMC9887252/ /pubmed/36719466 http://dx.doi.org/10.1007/s00251-023-01293-w Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review
Mora-Bitria, Laura
Asquith, Becca
Innate receptors modulating adaptive T cell responses: KIR-HLA interactions and T cell-mediated control of chronic viral infections
title Innate receptors modulating adaptive T cell responses: KIR-HLA interactions and T cell-mediated control of chronic viral infections
title_full Innate receptors modulating adaptive T cell responses: KIR-HLA interactions and T cell-mediated control of chronic viral infections
title_fullStr Innate receptors modulating adaptive T cell responses: KIR-HLA interactions and T cell-mediated control of chronic viral infections
title_full_unstemmed Innate receptors modulating adaptive T cell responses: KIR-HLA interactions and T cell-mediated control of chronic viral infections
title_short Innate receptors modulating adaptive T cell responses: KIR-HLA interactions and T cell-mediated control of chronic viral infections
title_sort innate receptors modulating adaptive t cell responses: kir-hla interactions and t cell-mediated control of chronic viral infections
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9887252/
https://www.ncbi.nlm.nih.gov/pubmed/36719466
http://dx.doi.org/10.1007/s00251-023-01293-w
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