PCSK9 deficiency alters brain lipid composition without affecting brain development and function

PCSK9 induces lysosomal degradation of the low-density lipoprotein (LDL) receptor (LDLR) in the liver, hereby preventing removal of LDL cholesterol from the circulation. Accordingly, PCSK9 inhibitory antibodies and siRNA potently reduce LDL cholesterol to unprecedented low levels and are approved fo...

Descripción completa

Detalles Bibliográficos
Autores principales: Pärn, Angela, Olsen, Ditte, Tuvikene, Jürgen, Kaas, Mathias, Borisova, Ekaterina, Bilgin, Mesut, Elhauge, Mie, Vilstrup, Joachim, Madsen, Peder, Ambrozkiewicz, Mateusz C., Goz, Roman U., Timmusk, Tõnis, Tarabykin, Victor, Gustafsen, Camilla, Glerup, Simon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Molecular Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9887304/
https://www.ncbi.nlm.nih.gov/pubmed/36733269
http://dx.doi.org/10.3389/fnmol.2022.1084633

Ejemplares similares

Ejemplares similares