Humoral and cellular immune response dynamics in Japanese healthcare workers up to six months after receiving a third dose of BNT162b2 monovalent vaccine

Longitudinal data on the immune response from the first dose to several months after the third dose of COVID-19 vaccine are limited. We analyzed the immune response in 406 Japanese healthcare workers who received at least three doses of vaccine. The geometric mean anti-receptor binding domain IgG an...

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Detalles Bibliográficos
Autores principales: Uwamino, Yoshifumi, Yokoyama, Takashi, Sato, Yasunori, Shibata, Ayako, Kurafuji, Toshinobu, Tanabe, Akiko, Noguchi, Masayo, Arai, Tomoko, Ohno, Akemi, Yokota, Hiromitsu, Namkoong, Ho, Nishimura, Tomoyasu, Kosaki, Kenjiro, Hasegawa, Naoki, Wakui, Masatoshi, Murata, Mitsuru, Matsushita, Hiromichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2023
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9887493/
https://www.ncbi.nlm.nih.gov/pubmed/36732167
http://dx.doi.org/10.1016/j.vaccine.2023.01.049
Descripción
Sumario:Longitudinal data on the immune response from the first dose to several months after the third dose of COVID-19 vaccine are limited. We analyzed the immune response in 406 Japanese healthcare workers who received at least three doses of vaccine. The geometric mean anti-receptor binding domain IgG antibody titers and antigen-stimulated T-cell interferon-gamma levels after 6 months after receiving a third dose were similar to those 8 weeks after receiving a second dose. Humoral and cellular immunity induced by the third dose was more durable than that induced by the second dose. UMIN Clinical Trials Registry ID: UMIN000043340.

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