Humoral and cellular immune response dynamics in Japanese healthcare workers up to six months after receiving a third dose of BNT162b2 monovalent vaccine

Longitudinal data on the immune response from the first dose to several months after the third dose of COVID-19 vaccine are limited. We analyzed the immune response in 406 Japanese healthcare workers who received at least three doses of vaccine. The geometric mean anti-receptor binding domain IgG an...

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Autores principales: Uwamino, Yoshifumi, Yokoyama, Takashi, Sato, Yasunori, Shibata, Ayako, Kurafuji, Toshinobu, Tanabe, Akiko, Noguchi, Masayo, Arai, Tomoko, Ohno, Akemi, Yokota, Hiromitsu, Namkoong, Ho, Nishimura, Tomoyasu, Kosaki, Kenjiro, Hasegawa, Naoki, Wakui, Masatoshi, Murata, Mitsuru, Matsushita, Hiromichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2023
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9887493/
https://www.ncbi.nlm.nih.gov/pubmed/36732167
http://dx.doi.org/10.1016/j.vaccine.2023.01.049
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author Uwamino, Yoshifumi
Yokoyama, Takashi
Sato, Yasunori
Shibata, Ayako
Kurafuji, Toshinobu
Tanabe, Akiko
Noguchi, Masayo
Arai, Tomoko
Ohno, Akemi
Yokota, Hiromitsu
Namkoong, Ho
Nishimura, Tomoyasu
Kosaki, Kenjiro
Hasegawa, Naoki
Wakui, Masatoshi
Murata, Mitsuru
Matsushita, Hiromichi
author_facet Uwamino, Yoshifumi
Yokoyama, Takashi
Sato, Yasunori
Shibata, Ayako
Kurafuji, Toshinobu
Tanabe, Akiko
Noguchi, Masayo
Arai, Tomoko
Ohno, Akemi
Yokota, Hiromitsu
Namkoong, Ho
Nishimura, Tomoyasu
Kosaki, Kenjiro
Hasegawa, Naoki
Wakui, Masatoshi
Murata, Mitsuru
Matsushita, Hiromichi
author_sort Uwamino, Yoshifumi
collection PubMed
description Longitudinal data on the immune response from the first dose to several months after the third dose of COVID-19 vaccine are limited. We analyzed the immune response in 406 Japanese healthcare workers who received at least three doses of vaccine. The geometric mean anti-receptor binding domain IgG antibody titers and antigen-stimulated T-cell interferon-gamma levels after 6 months after receiving a third dose were similar to those 8 weeks after receiving a second dose. Humoral and cellular immunity induced by the third dose was more durable than that induced by the second dose. UMIN Clinical Trials Registry ID: UMIN000043340.
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spelling pubmed-98874932023-01-31 Humoral and cellular immune response dynamics in Japanese healthcare workers up to six months after receiving a third dose of BNT162b2 monovalent vaccine Uwamino, Yoshifumi Yokoyama, Takashi Sato, Yasunori Shibata, Ayako Kurafuji, Toshinobu Tanabe, Akiko Noguchi, Masayo Arai, Tomoko Ohno, Akemi Yokota, Hiromitsu Namkoong, Ho Nishimura, Tomoyasu Kosaki, Kenjiro Hasegawa, Naoki Wakui, Masatoshi Murata, Mitsuru Matsushita, Hiromichi Vaccine Short Communication Longitudinal data on the immune response from the first dose to several months after the third dose of COVID-19 vaccine are limited. We analyzed the immune response in 406 Japanese healthcare workers who received at least three doses of vaccine. The geometric mean anti-receptor binding domain IgG antibody titers and antigen-stimulated T-cell interferon-gamma levels after 6 months after receiving a third dose were similar to those 8 weeks after receiving a second dose. Humoral and cellular immunity induced by the third dose was more durable than that induced by the second dose. UMIN Clinical Trials Registry ID: UMIN000043340. Elsevier Ltd. 2023-02-24 2023-01-31 /pmc/articles/PMC9887493/ /pubmed/36732167 http://dx.doi.org/10.1016/j.vaccine.2023.01.049 Text en © 2023 Elsevier Ltd. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Short Communication
Uwamino, Yoshifumi
Yokoyama, Takashi
Sato, Yasunori
Shibata, Ayako
Kurafuji, Toshinobu
Tanabe, Akiko
Noguchi, Masayo
Arai, Tomoko
Ohno, Akemi
Yokota, Hiromitsu
Namkoong, Ho
Nishimura, Tomoyasu
Kosaki, Kenjiro
Hasegawa, Naoki
Wakui, Masatoshi
Murata, Mitsuru
Matsushita, Hiromichi
Humoral and cellular immune response dynamics in Japanese healthcare workers up to six months after receiving a third dose of BNT162b2 monovalent vaccine
title Humoral and cellular immune response dynamics in Japanese healthcare workers up to six months after receiving a third dose of BNT162b2 monovalent vaccine
title_full Humoral and cellular immune response dynamics in Japanese healthcare workers up to six months after receiving a third dose of BNT162b2 monovalent vaccine
title_fullStr Humoral and cellular immune response dynamics in Japanese healthcare workers up to six months after receiving a third dose of BNT162b2 monovalent vaccine
title_full_unstemmed Humoral and cellular immune response dynamics in Japanese healthcare workers up to six months after receiving a third dose of BNT162b2 monovalent vaccine
title_short Humoral and cellular immune response dynamics in Japanese healthcare workers up to six months after receiving a third dose of BNT162b2 monovalent vaccine
title_sort humoral and cellular immune response dynamics in japanese healthcare workers up to six months after receiving a third dose of bnt162b2 monovalent vaccine
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9887493/
https://www.ncbi.nlm.nih.gov/pubmed/36732167
http://dx.doi.org/10.1016/j.vaccine.2023.01.049
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