Kinase PLK1 regulates the disassembly of the lateral elements and the assembly of the inner centromere during the diakinesis/metaphase I transition in male mouse meiosis

PLK1 is a serine/threonine kinase with crucial roles during mitosis. However, its involvement during mammalian male meiosis remains largely unexplored. By inhibiting the kinase activity of PLK1 using BI 2536 on organotypic cultures of seminiferous tubules, we found that the disassembly of SYCP3 and...

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Detalles Bibliográficos
Autores principales: Gómez, Rocío, Viera, Alberto, Moreno-Mármol, Tania, Berenguer, Inés, Guajardo-Grence, Andrea, Tóth, Attila, Parra, María Teresa, Suja, José A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9887526/
https://www.ncbi.nlm.nih.gov/pubmed/36733339
http://dx.doi.org/10.3389/fcell.2022.1069946

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