Ocrelizumab Impairs the Phenotype and Function of Memory CD8(+) T Cells: A 1-Year Longitudinal Study in Patients With Multiple Sclerosis

BACKGROUND AND OBJECTIVE: Depleting CD20(+) B cells is the primary mechanism by which ocrelizumab (OCRE) is efficient in persons with multiple sclerosis (pwMS). However, the exact role of OCRE on other immune cell subsets directly or indirectly remains elusive. The purpose of this study is to charac...

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Detalles Bibliográficos
Autores principales: Mathias, Amandine, Pantazou, Vasiliki, Perriot, Sylvain, Canales, Mathieu, Jones, Samuel, Oberholster, Larise, Moulin, Michaël, Fenwick, Craig, Bernard-Valnet, Raphaël, Théaudin, Marie, Pot, Caroline, Du Pasquier, Renaud A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9887539/
https://www.ncbi.nlm.nih.gov/pubmed/36717268
http://dx.doi.org/10.1212/NXI.0000000000200084

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