Effects of bacterial and viral pathogen-associated molecular patterns (PAMPs) on multidrug resistance (MDR) transporters in brain endothelial cells of the developing human blood–brain barrier

BACKGROUND: The multidrug resistance (MDR) transporters, P-glycoprotein (P-gp, encoded by ABCB1) and breast cancer resistance protein (BCRP/ABCG2) contribute to the blood–brain barrier (BBB), protecting the brain from drug exposure. The impact of infection on MDR in the developing human BBB remains...

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Detalles Bibliográficos
Autores principales: Lye, Phetcharawan, Bloise, Enrrico, Matthews, Stephen G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9887585/
https://www.ncbi.nlm.nih.gov/pubmed/36721242
http://dx.doi.org/10.1186/s12987-023-00409-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9887585/
https://www.ncbi.nlm.nih.gov/pubmed/36721242
http://dx.doi.org/10.1186/s12987-023-00409-4

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