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Predicting human cardiac QT alterations and pro-arrhythmic effects of compounds with a 3D beating heart-on-chip platform

Determining the potential cardiotoxicity and pro-arrhythmic effects of drug candidates remains one of the most relevant issues in the drug development pipeline (DDP). New methods enabling to perform more representative preclinical in vitro studies by exploiting induced pluripotent stem cell-derived...

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Detalles Bibliográficos
Autores principales:	Visone, Roberta, Lozano-Juan, Ferran, Marzorati, Simona, Rivolta, Massimo Walter, Pesenti, Enrico, Redaelli, Alberto, Sassi, Roberto, Rasponi, Marco, Occhetta, Paola
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2022
Materias:	Emerging Technologies, Methods, and Models
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9887672/ https://www.ncbi.nlm.nih.gov/pubmed/36226800 http://dx.doi.org/10.1093/toxsci/kfac108

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