Relative contributions of endogenous and exogenous formaldehyde to formation of deoxyguanosine monoadducts and DNA-protein crosslink adducts of DNA in rat nasal mucosa

Understanding the dose-response for formaldehyde-induced nasal cancer in rats is complicated by (1) the uneven distribution of inhaled formaldehyde across the interior surface of the nasal cavity and, (2) the presence of endogenous formaldehyde (endoF) in the nasal mucosa. In this work, we used comp...

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Detalles Bibliográficos
Autores principales: Conolly, Rory B, Campbell, Jerry L, Clewell, Harvey J, Schroeter, Jeffry, Kimbell, Julia S, Gentry, P Robinan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Biotransformation, Toxicokinetics, and Pharmacokinetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9887723/
https://www.ncbi.nlm.nih.gov/pubmed/36409013
http://dx.doi.org/10.1093/toxsci/kfac119

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9887723/
https://www.ncbi.nlm.nih.gov/pubmed/36409013
http://dx.doi.org/10.1093/toxsci/kfac119

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