In vitro co-culture systems of hepatic and intestinal cells for cellular pharmacokinetic and pharmacodynamic studies of capecitabine against colorectal cancer

BACKGROUND: As a prodrug of 5-fluorouracil (5-FU), orally administrated capecitabine (CAP) undergoes preliminary conversion into active metabolites in the liver and then releases 5-FU in the gut to exert the anti-tumor activity. Since metabolic changes of CAP play a key role in its activation, a sin...

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Detalles Bibliográficos
Autores principales: Ge, Chun, Huang, Xintong, Zhang, Sujie, Yuan, Man, Tan, Zhaoyi, Xu, Chen, Jie, Qiong, Zhang, Jingjing, Zou, Jianjun, Zhu, Yubing, Feng, Dong, Zhang, Yue, Aa, Jiye
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9887786/
https://www.ncbi.nlm.nih.gov/pubmed/36717845
http://dx.doi.org/10.1186/s12935-023-02853-6

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