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Sex-specific effects of calving season on joint health and biomarkers in Montana ranchers

BACKGROUND: Agricultural workers have a higher incidence of osteoarthritis (OA), but the etiology behind this phenomenon is unclear. Calving season, which occurs in mid- to late-winter for ranchers, includes physical conditions that may elevate OA risk. Our primary aim was to determine whether OA bi...

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Autores principales: Thompson, Matthew A., Martin, Stephen A., Hislop, Brady D., Younkin, Roubie, Andrews, Tara M., Miller, Kaleena, June, Ronald K., Adams, Erik S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9887842/
https://www.ncbi.nlm.nih.gov/pubmed/36717802
http://dx.doi.org/10.1186/s12891-022-05979-2
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author Thompson, Matthew A.
Martin, Stephen A.
Hislop, Brady D.
Younkin, Roubie
Andrews, Tara M.
Miller, Kaleena
June, Ronald K.
Adams, Erik S.
author_facet Thompson, Matthew A.
Martin, Stephen A.
Hislop, Brady D.
Younkin, Roubie
Andrews, Tara M.
Miller, Kaleena
June, Ronald K.
Adams, Erik S.
author_sort Thompson, Matthew A.
collection PubMed
description BACKGROUND: Agricultural workers have a higher incidence of osteoarthritis (OA), but the etiology behind this phenomenon is unclear. Calving season, which occurs in mid- to late-winter for ranchers, includes physical conditions that may elevate OA risk. Our primary aim was to determine whether OA biomarkers are elevated at the peak of calving season compared to pre-season, and to compare these data with joint health survey information from the subjects. Our secondary aim was to detect biomarker differences between male and female ranchers. METHODS: During collection periods before and during calving season, male (n = 28) and female (n = 10) ranchers completed joint health surveys and provided samples of blood, urine, and saliva for biomarker analysis. Statistical analyses examined associations between mean biomarker levels and survey predictors. Ensemble cluster analysis identified groups having unique biomarker profiles. RESULTS: The number of calvings performed by each rancher positively correlated with plasma IL-6, serum hyaluronic acid (HA) and urinary CTX-I. Thiobarbituric acid reactive substances (TBARS), a marker of oxidative stress, was significantly higher during calving season than pre-season and was also correlated with ranchers having more months per year of joint pain. We found evidence of sexual dimorphism in the biomarkers among the ranchers, with leptin being elevated and matrix metalloproteinase-3 diminished in female ranchers. The opposite was detected in males. WOMAC score was positively associated with multiple biomarkers: IL-6, IL-2, HA, leptin, C2C, asymmetric dimethylarginine, and CTX-I. These biomarkers represent enzymatic degradation, inflammation, products of joint destruction, and OA severity. CONCLUSIONS: The positive association between number of calvings performed by each rancher (workload) and both inflammatory and joint tissue catabolism biomarkers establishes that calving season is a risk factor for OA in Montana ranchers. Consistent with the literature, we found important sex differences in OA biomarkers, with female ranchers showing elevated leptin, whereas males showed elevated MMP-3. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12891-022-05979-2.
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spelling pubmed-98878422023-02-01 Sex-specific effects of calving season on joint health and biomarkers in Montana ranchers Thompson, Matthew A. Martin, Stephen A. Hislop, Brady D. Younkin, Roubie Andrews, Tara M. Miller, Kaleena June, Ronald K. Adams, Erik S. BMC Musculoskelet Disord Research BACKGROUND: Agricultural workers have a higher incidence of osteoarthritis (OA), but the etiology behind this phenomenon is unclear. Calving season, which occurs in mid- to late-winter for ranchers, includes physical conditions that may elevate OA risk. Our primary aim was to determine whether OA biomarkers are elevated at the peak of calving season compared to pre-season, and to compare these data with joint health survey information from the subjects. Our secondary aim was to detect biomarker differences between male and female ranchers. METHODS: During collection periods before and during calving season, male (n = 28) and female (n = 10) ranchers completed joint health surveys and provided samples of blood, urine, and saliva for biomarker analysis. Statistical analyses examined associations between mean biomarker levels and survey predictors. Ensemble cluster analysis identified groups having unique biomarker profiles. RESULTS: The number of calvings performed by each rancher positively correlated with plasma IL-6, serum hyaluronic acid (HA) and urinary CTX-I. Thiobarbituric acid reactive substances (TBARS), a marker of oxidative stress, was significantly higher during calving season than pre-season and was also correlated with ranchers having more months per year of joint pain. We found evidence of sexual dimorphism in the biomarkers among the ranchers, with leptin being elevated and matrix metalloproteinase-3 diminished in female ranchers. The opposite was detected in males. WOMAC score was positively associated with multiple biomarkers: IL-6, IL-2, HA, leptin, C2C, asymmetric dimethylarginine, and CTX-I. These biomarkers represent enzymatic degradation, inflammation, products of joint destruction, and OA severity. CONCLUSIONS: The positive association between number of calvings performed by each rancher (workload) and both inflammatory and joint tissue catabolism biomarkers establishes that calving season is a risk factor for OA in Montana ranchers. Consistent with the literature, we found important sex differences in OA biomarkers, with female ranchers showing elevated leptin, whereas males showed elevated MMP-3. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12891-022-05979-2. BioMed Central 2023-01-31 /pmc/articles/PMC9887842/ /pubmed/36717802 http://dx.doi.org/10.1186/s12891-022-05979-2 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Thompson, Matthew A.
Martin, Stephen A.
Hislop, Brady D.
Younkin, Roubie
Andrews, Tara M.
Miller, Kaleena
June, Ronald K.
Adams, Erik S.
Sex-specific effects of calving season on joint health and biomarkers in Montana ranchers
title Sex-specific effects of calving season on joint health and biomarkers in Montana ranchers
title_full Sex-specific effects of calving season on joint health and biomarkers in Montana ranchers
title_fullStr Sex-specific effects of calving season on joint health and biomarkers in Montana ranchers
title_full_unstemmed Sex-specific effects of calving season on joint health and biomarkers in Montana ranchers
title_short Sex-specific effects of calving season on joint health and biomarkers in Montana ranchers
title_sort sex-specific effects of calving season on joint health and biomarkers in montana ranchers
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9887842/
https://www.ncbi.nlm.nih.gov/pubmed/36717802
http://dx.doi.org/10.1186/s12891-022-05979-2
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