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Seroprevalence and risk factors for Kaposi’s Sarcoma associated herpesvirus among men who have sex with men in Shanghai, China

BACKGROUND: This study aimed to facilitate the understanding of the transmission route and risk factors that might contribute to the infection of Kaposi’s sarcoma associated herpesvirus (KSHV) among men who have sex with men (MSM). METHODS: A cross-sectional study of 520 subjects was conducted in Sh...

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Autores principales: Li, Yi, Zhang, Xingcan, Zhang, Yue, Wei, Minqi, Tao, Sijie, Yang, Ying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9887846/
https://www.ncbi.nlm.nih.gov/pubmed/36721125
http://dx.doi.org/10.1186/s12879-023-08028-y
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author Li, Yi
Zhang, Xingcan
Zhang, Yue
Wei, Minqi
Tao, Sijie
Yang, Ying
author_facet Li, Yi
Zhang, Xingcan
Zhang, Yue
Wei, Minqi
Tao, Sijie
Yang, Ying
author_sort Li, Yi
collection PubMed
description BACKGROUND: This study aimed to facilitate the understanding of the transmission route and risk factors that might contribute to the infection of Kaposi’s sarcoma associated herpesvirus (KSHV) among men who have sex with men (MSM). METHODS: A cross-sectional study of 520 subjects was conducted in Shanghai, China in 2020. Plasma samples were collected and screened for KSHV, HIV, HBV, HCV, and syphilis. Univariate and multivariate logistic regression analyses were conducted to explore potential correlates of KSHV infection. RESULTS: The overall seroprevalence of KSHV was 43.8%, with an adjusted value of 29.8% according to the sensitivity and specificity of the KSHV screening assay. Individuals with lower levels of monthly income (Chi-sqaure(trend) = 4.11, P = 0.043) and more male sex partners (Chi-sqaure(trend) = 6.06, P = 0.014) were more likely to be infected with KSHV. Also, KSHV seropositivity was positively associated with being a student (aOR = 1.96; 95%CI: 1.09–3.61), being coinfected with HCV (aOR = 2.61; 95%CI: 1.05–7.10), and syphilis (aOR = 2.91; 95%CI: 1.30–6.89). CONCLUSIONS: The prevalence of KSHV in MSM remains high. As a risky sexual behavior, having multiple male sex partners is a key contributor to KSHV infection among this population. Efforts designed to control modifiable risk factors in order to reduce the burden of KSHV infection are indispensable. High KSHV seroprevalence among students MSM deserves more attention. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12879-023-08028-y.
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spelling pubmed-98878462023-02-01 Seroprevalence and risk factors for Kaposi’s Sarcoma associated herpesvirus among men who have sex with men in Shanghai, China Li, Yi Zhang, Xingcan Zhang, Yue Wei, Minqi Tao, Sijie Yang, Ying BMC Infect Dis Research BACKGROUND: This study aimed to facilitate the understanding of the transmission route and risk factors that might contribute to the infection of Kaposi’s sarcoma associated herpesvirus (KSHV) among men who have sex with men (MSM). METHODS: A cross-sectional study of 520 subjects was conducted in Shanghai, China in 2020. Plasma samples were collected and screened for KSHV, HIV, HBV, HCV, and syphilis. Univariate and multivariate logistic regression analyses were conducted to explore potential correlates of KSHV infection. RESULTS: The overall seroprevalence of KSHV was 43.8%, with an adjusted value of 29.8% according to the sensitivity and specificity of the KSHV screening assay. Individuals with lower levels of monthly income (Chi-sqaure(trend) = 4.11, P = 0.043) and more male sex partners (Chi-sqaure(trend) = 6.06, P = 0.014) were more likely to be infected with KSHV. Also, KSHV seropositivity was positively associated with being a student (aOR = 1.96; 95%CI: 1.09–3.61), being coinfected with HCV (aOR = 2.61; 95%CI: 1.05–7.10), and syphilis (aOR = 2.91; 95%CI: 1.30–6.89). CONCLUSIONS: The prevalence of KSHV in MSM remains high. As a risky sexual behavior, having multiple male sex partners is a key contributor to KSHV infection among this population. Efforts designed to control modifiable risk factors in order to reduce the burden of KSHV infection are indispensable. High KSHV seroprevalence among students MSM deserves more attention. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12879-023-08028-y. BioMed Central 2023-01-31 /pmc/articles/PMC9887846/ /pubmed/36721125 http://dx.doi.org/10.1186/s12879-023-08028-y Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Li, Yi
Zhang, Xingcan
Zhang, Yue
Wei, Minqi
Tao, Sijie
Yang, Ying
Seroprevalence and risk factors for Kaposi’s Sarcoma associated herpesvirus among men who have sex with men in Shanghai, China
title Seroprevalence and risk factors for Kaposi’s Sarcoma associated herpesvirus among men who have sex with men in Shanghai, China
title_full Seroprevalence and risk factors for Kaposi’s Sarcoma associated herpesvirus among men who have sex with men in Shanghai, China
title_fullStr Seroprevalence and risk factors for Kaposi’s Sarcoma associated herpesvirus among men who have sex with men in Shanghai, China
title_full_unstemmed Seroprevalence and risk factors for Kaposi’s Sarcoma associated herpesvirus among men who have sex with men in Shanghai, China
title_short Seroprevalence and risk factors for Kaposi’s Sarcoma associated herpesvirus among men who have sex with men in Shanghai, China
title_sort seroprevalence and risk factors for kaposi’s sarcoma associated herpesvirus among men who have sex with men in shanghai, china
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9887846/
https://www.ncbi.nlm.nih.gov/pubmed/36721125
http://dx.doi.org/10.1186/s12879-023-08028-y
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