Lysyl hydroxylase LH1 promotes confined migration and metastasis of cancer cells by stabilizing Septin2 to enhance actin network

BACKGROUND: Excessive extracellular matrix deposition and increased stiffness are typical features of solid tumors such as hepatocellular carcinoma (HCC) and pancreatic ductal adenocarcinoma (PDAC). These conditions create confined spaces for tumor cell migration and metastasis. The regulatory mecha...

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Detalles Bibliográficos
Autores principales: Yang, Zihan, Zhou, Li, Si, Tongxu, Chen, Siyuan, Liu, Chengxi, Ng, Kelvin Kaki, Wang, Zesheng, Chen, Zhiji, Qiu, Chan, Liu, Guopan, Wang, Qingliang, Zhou, Xiaoyu, Zhang, Liang, Yao, Zhongping, He, Song, Yang, Mengsu, Zhou, Zhihang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9887875/
https://www.ncbi.nlm.nih.gov/pubmed/36721170
http://dx.doi.org/10.1186/s12943-023-01727-9

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