2-Hydroxy-3-methylanthraquinone inhibits homologous recombination repair in osteosarcoma through the MYC-CHK1-RAD51 axis

BACKGROUND: Osteosarcoma is a malignant bone tumor that usually affects adolescents aged 15–19 y. The DNA damage response (DDR) is significantly enhanced in osteosarcoma, impairing the effect of systemic chemotherapy. Targeting the DDR process was considered a feasible strategy benefitting osteosarc...

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Detalles Bibliográficos
Autores principales: Jing, Doudou, Chen, Xuanzuo, Zhang, Zhenhao, Chen, Fengxia, Huang, Fuhua, Zhang, Zhicai, Wu, Wei, Shao, Zengwu, Pu, Feifei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9887913/
https://www.ncbi.nlm.nih.gov/pubmed/36717782
http://dx.doi.org/10.1186/s10020-023-00611-y

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