Amyloid beta accumulations and enhanced neuronal differentiation in cerebral organoids of Dutch-type cerebral amyloid angiopathy patients

INTRODUCTION: ADutch-type cerebral amyloid angiopathy (D-CAA) is a hereditary brain disorder caused by a point mutation in the amyloid precursor protein (APP) gene. The mutation is located within the amyloid beta (Aβ) domain of APP and leads to Aβ peptide accumulation in and around the cerebral vasc...

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Detalles Bibliográficos
Autores principales: Daoutsali, Elena, Pepers, Barry A., Stamatakis, Stavros, van der Graaf, Linda M., Terwindt, Gisela M., Parfitt, David A., Buijsen, Ronald A. M., van Roon-Mom, Willeke M. C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Aging Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9887998/
https://www.ncbi.nlm.nih.gov/pubmed/36733499
http://dx.doi.org/10.3389/fnagi.2022.1048584

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