A Nuclear Export Signal in KHNYN Required for Its Antiviral Activity Evolved as ZAP Emerged in Tetrapods

The zinc finger antiviral protein (ZAP) inhibits viral replication by directly binding CpG dinucleotides in cytoplasmic viral RNA to inhibit protein synthesis and target the RNA for degradation. ZAP evolved in tetrapods and there are clear orthologs in reptiles, birds, and mammals. When ZAP emerged,...

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Detalles Bibliográficos
Autores principales: Lista, Maria J., Ficarelli, Mattia, Wilson, Harry, Kmiec, Dorota, Youle, Rebecca L., Wanford, Joseph, Winstone, Helena, Odendall, Charlotte, Taylor, Ian A., Neil, Stuart J. D., Swanson, Chad M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2023
Materias:
Virus-Cell Interactions
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9888277/
https://www.ncbi.nlm.nih.gov/pubmed/36633408
http://dx.doi.org/10.1128/jvi.00872-22

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9888277/
https://www.ncbi.nlm.nih.gov/pubmed/36633408
http://dx.doi.org/10.1128/jvi.00872-22

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