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Monkeypox virus replication underlying circadian rhythm networks
The mammalian brain has an endogenous central circadian clock that regulates central and peripheral cellular activities. At the molecular level, this day-night cycle induces the expression of upstream and downstream transcription factors that influence the immune system and the severity of viral inf...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer International Publishing
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9888333/ https://www.ncbi.nlm.nih.gov/pubmed/36719593 http://dx.doi.org/10.1007/s13365-023-01118-2 |
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author | Zandi, Milad Shafaati, Maryam Shapshak, Paul Hashemnia, Seyyed Mohammad Reza |
author_facet | Zandi, Milad Shafaati, Maryam Shapshak, Paul Hashemnia, Seyyed Mohammad Reza |
author_sort | Zandi, Milad |
collection | PubMed |
description | The mammalian brain has an endogenous central circadian clock that regulates central and peripheral cellular activities. At the molecular level, this day-night cycle induces the expression of upstream and downstream transcription factors that influence the immune system and the severity of viral infections over time. In addition, there are also circadian effects on host tolerance pathways. This stimulates adaptation to normal changes in environmental conditions and requirements (including light and food). These rhythms influence the pharmacokinetics and efficacy of therapeutic drugs and vaccines. The importance of circadian systems in regulating viral infections and the host response to viruses is currently of great importance for clinical management. With the knowledge gained from the COVID-19 pandemic, it is important to address any outbreak of viral infection that could become endemic and to quickly focus research on any knowledge gaps. For example, responses to booster vaccination COVID-19 may have different time-dependent patterns during circadian cycles. There may be a link between reactivation of latently infected viruses and regulation of circadian rhythms. In addition, mammals may show different seasonal antiviral responses in winter and summer. This article discusses the importance of the host circadian clock during monkeypox infection and immune system interactions. |
format | Online Article Text |
id | pubmed-9888333 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Springer International Publishing |
record_format | MEDLINE/PubMed |
spelling | pubmed-98883332023-02-01 Monkeypox virus replication underlying circadian rhythm networks Zandi, Milad Shafaati, Maryam Shapshak, Paul Hashemnia, Seyyed Mohammad Reza J Neurovirol Mini-Review The mammalian brain has an endogenous central circadian clock that regulates central and peripheral cellular activities. At the molecular level, this day-night cycle induces the expression of upstream and downstream transcription factors that influence the immune system and the severity of viral infections over time. In addition, there are also circadian effects on host tolerance pathways. This stimulates adaptation to normal changes in environmental conditions and requirements (including light and food). These rhythms influence the pharmacokinetics and efficacy of therapeutic drugs and vaccines. The importance of circadian systems in regulating viral infections and the host response to viruses is currently of great importance for clinical management. With the knowledge gained from the COVID-19 pandemic, it is important to address any outbreak of viral infection that could become endemic and to quickly focus research on any knowledge gaps. For example, responses to booster vaccination COVID-19 may have different time-dependent patterns during circadian cycles. There may be a link between reactivation of latently infected viruses and regulation of circadian rhythms. In addition, mammals may show different seasonal antiviral responses in winter and summer. This article discusses the importance of the host circadian clock during monkeypox infection and immune system interactions. Springer International Publishing 2023-01-31 2023 /pmc/articles/PMC9888333/ /pubmed/36719593 http://dx.doi.org/10.1007/s13365-023-01118-2 Text en © This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply 2023 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic. |
spellingShingle | Mini-Review Zandi, Milad Shafaati, Maryam Shapshak, Paul Hashemnia, Seyyed Mohammad Reza Monkeypox virus replication underlying circadian rhythm networks |
title | Monkeypox virus replication underlying circadian rhythm networks |
title_full | Monkeypox virus replication underlying circadian rhythm networks |
title_fullStr | Monkeypox virus replication underlying circadian rhythm networks |
title_full_unstemmed | Monkeypox virus replication underlying circadian rhythm networks |
title_short | Monkeypox virus replication underlying circadian rhythm networks |
title_sort | monkeypox virus replication underlying circadian rhythm networks |
topic | Mini-Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9888333/ https://www.ncbi.nlm.nih.gov/pubmed/36719593 http://dx.doi.org/10.1007/s13365-023-01118-2 |
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