IFN-γR/STAT1 signaling in recipient hematopoietic antigen-presenting cells suppresses graft-versus-host disease

The absence of IFN-γ receptor (IFN-γR) or STAT1 signaling in donor cells has been shown to result in reduced induction of acute graft-versus-host disease (GVHD). In this study, we unexpectedly observed increased activation and expansion of donor lymphocytes in both lymphohematopoietic organs and GVH...

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Detalles Bibliográficos
Autores principales: Lu, Caisheng, Ma, Huihui, Song, Liangsong, Wang, Hui, Wang, Lily, Li, Shirong, Lagana, Stephen M., Sepulveda, Antonia R., Hoebe, Kasper, Pan, Samuel S., Yang, Yong-Guang, Lentzsch, Suzanne, Mapara, Markus Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9888368/
https://www.ncbi.nlm.nih.gov/pubmed/36445781
http://dx.doi.org/10.1172/JCI125986

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