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Striving toward hyperthermia-free analgesia: lessons from loss-of-function mutations of human TRPV1
Transient receptor potential vanilloid 1 (TRPV1), a receptor for capsaicin and noxious heat, has been one of the most compelling targets for analgesics. However, systemic inhibition of TRPV1 is an impractical approach as a pain killer, since systemic antagonism induces hyperthermia. Two articles in...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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American Society for Clinical Investigation
2023
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9888373/ https://www.ncbi.nlm.nih.gov/pubmed/36719371 http://dx.doi.org/10.1172/JCI167338 |