NLRP12 is an innate immune checkpoint for repressing IFN signatures and attenuating lupus nephritis progression

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Signaling driven by nucleic acid sensors participates in interferonopathy-mediated autoimmune diseases. NLRP12, a pyrin-containing NLR protein, is a negative regulator of innate immune activation and type I interferon (IFN-I) production. Peripheral blood mononuclear cells (PBMCs) derived from system...

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Detalles Bibliográficos
Autores principales: Tsao, Yen-Po, Tseng, Fang-Yu, Chao, Chih-Wei, Chen, Ming-Han, Yeh, Yi-Chen, Abdulkareem, Babamale Olarewaju, Chen, Se-Yi, Chuang, Wen-Ting, Chang, Pei-Ching, Chen, I-Chun, Wang, Pin-Hsuan, Wu, Chien-Sheng, Tsai, Chang-Youh, Chen, Szu-Ting
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9888378/
https://www.ncbi.nlm.nih.gov/pubmed/36719379
http://dx.doi.org/10.1172/JCI157272
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