Glucose- and glutamine-dependent bioenergetics sensitize bone mechanoresponse after unloading by modulating osteocyte calcium dynamics

Disuse osteoporosis is a metabolic bone disease resulting from skeletal unloading (e.g., during extended bed rest, limb immobilization, and spaceflight), and the slow and insufficient bone recovery during reambulation remains an unresolved medical challenge. Here, we demonstrated that loading-induce...

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Detalles Bibliográficos
Autores principales: Liu, Xiyu, Yan, Zedong, Cai, Jing, Wang, Dan, Yang, Yongqing, Ding, Yuanjun, Shao, Xi, Hao, Xiaoxia, Luo, Erping, Guo, X. Edward, Luo, Peng, Shen, Liangliang, Jing, Da
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9888392/
https://www.ncbi.nlm.nih.gov/pubmed/36512405
http://dx.doi.org/10.1172/JCI164508

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