PD-L1 translocation to the plasma membrane enables tumor immune evasion through MIB2 ubiquitination

Programmed death-ligand 1 (PD-L1), a critical immune checkpoint ligand, is a transmembrane protein synthesized in the endoplasmic reticulum of tumor cells and transported to the plasma membrane to interact with programmed death 1 (PD-1) expressed on T cell surface. This interaction delivers coinhibi...

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Detalles Bibliográficos
Autores principales: Yu, Xinfang, Li, Wei, Liu, Haidan, Wang, Xu, Coarfa, Cristian, Cheng, Chao, Yu, Xinlian, Zeng, Zhaoyang, Cao, Ya, Young, Ken H., Li, Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9888393/
https://www.ncbi.nlm.nih.gov/pubmed/36719382
http://dx.doi.org/10.1172/JCI160456

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