Polygenic resilience score may be sensitive to preclinical Alzheimer’s disease changes

Late-onset Alzheimer’s disease (LOAD) is a polygenic disorder with a long prodromal phase, making early diagnosis challenging. Twin studies estimate LOAD as 60–80% heritable, and while common genetic variants can account for 30% of this heritability, nearly 70% remains “missing”. Polygenic risk scor...

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Detalles Bibliográficos
Autores principales: Eissman, Jaclyn M., Wells, Greyson, Khan, Omair A., Liu, Dandan, Petyuk, Vladislav A., Gifford, Katherine A., Dumitrescu, Logan, Jefferson, Angela L., Hohman, Timothy J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9888419/
https://www.ncbi.nlm.nih.gov/pubmed/36540999

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