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Tailoring and optimization of a honey-based nanoemulgel loaded with an itraconazole–thyme oil nanoemulsion for oral candidiasis
The use of essential oil–based nanoemulsions (NEs) has been the subject of extensive research on a variety of conditions affecting the oral cavity. NEs are delivery methods that improve the solubility and distribution of lipid medicines to the intended areas. Because of their antibacterial and antif...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Taylor & Francis
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9888461/ https://www.ncbi.nlm.nih.gov/pubmed/36708105 http://dx.doi.org/10.1080/10717544.2023.2173337 |
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author | Sindi, Amal M. Rizg, Waleed Y. Khan, Muhammad Khalid Alkhalidi, Hala M. Alharbi, Waleed S. Sabei, Fahad Y. Alfayez, Eman Alkharobi, Hanaa Korayem, Mohammed Majrashi, Mohammed Alharbi, Majed Alissa, Mohammed Safhi, Awaji Y. Jali, Abdulmajeed M. Hosny, Khaled M. |
author_facet | Sindi, Amal M. Rizg, Waleed Y. Khan, Muhammad Khalid Alkhalidi, Hala M. Alharbi, Waleed S. Sabei, Fahad Y. Alfayez, Eman Alkharobi, Hanaa Korayem, Mohammed Majrashi, Mohammed Alharbi, Majed Alissa, Mohammed Safhi, Awaji Y. Jali, Abdulmajeed M. Hosny, Khaled M. |
author_sort | Sindi, Amal M. |
collection | PubMed |
description | The use of essential oil–based nanoemulsions (NEs) has been the subject of extensive research on a variety of conditions affecting the oral cavity. NEs are delivery methods that improve the solubility and distribution of lipid medicines to the intended areas. Because of their antibacterial and antifungal properties, itraconazole and thyme oil–based self-nanoemulsifying drug delivery systems (ItZ-ThO-SNEDDS) were created to protect oral health against oral microorganisms. The ItZ-ThO-SNEDDS were created utilizing an extreme verices mixture design, and varying concentrations of ThO (10% and 25%), labrasol (40% and 70%), and transcutol (20% and 40%) were used. The ItZ-ThO-SNEDDS had droplet sizes of less than 250 nm, a drug-loading efficiency of up to 64%, and a fungal growth inhibition zone of up to 20 mm. The accepted design was used to obtain the ideal formulation, which contained ThO in the amount of 0.18 g/ml, labrasol 0.62 g/ml, and transcutol 0.2 g/ml. The best ItZ-ThO-SNEDDS formulation was incorporated into a honey-based gel, which demonstrated improved release of ItZ in vitro and improved transbuccal permeation ex vivo. In addition, when compared with various formulations tested in rats, the optimized loaded emulgel decreased the ulcer index. This study therefore demonstrated that the ItZ-ThO-SNEDDS could offer an effective defense against oral diseases caused by microbial infections. |
format | Online Article Text |
id | pubmed-9888461 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Taylor & Francis |
record_format | MEDLINE/PubMed |
spelling | pubmed-98884612023-02-01 Tailoring and optimization of a honey-based nanoemulgel loaded with an itraconazole–thyme oil nanoemulsion for oral candidiasis Sindi, Amal M. Rizg, Waleed Y. Khan, Muhammad Khalid Alkhalidi, Hala M. Alharbi, Waleed S. Sabei, Fahad Y. Alfayez, Eman Alkharobi, Hanaa Korayem, Mohammed Majrashi, Mohammed Alharbi, Majed Alissa, Mohammed Safhi, Awaji Y. Jali, Abdulmajeed M. Hosny, Khaled M. Drug Deliv Article The use of essential oil–based nanoemulsions (NEs) has been the subject of extensive research on a variety of conditions affecting the oral cavity. NEs are delivery methods that improve the solubility and distribution of lipid medicines to the intended areas. Because of their antibacterial and antifungal properties, itraconazole and thyme oil–based self-nanoemulsifying drug delivery systems (ItZ-ThO-SNEDDS) were created to protect oral health against oral microorganisms. The ItZ-ThO-SNEDDS were created utilizing an extreme verices mixture design, and varying concentrations of ThO (10% and 25%), labrasol (40% and 70%), and transcutol (20% and 40%) were used. The ItZ-ThO-SNEDDS had droplet sizes of less than 250 nm, a drug-loading efficiency of up to 64%, and a fungal growth inhibition zone of up to 20 mm. The accepted design was used to obtain the ideal formulation, which contained ThO in the amount of 0.18 g/ml, labrasol 0.62 g/ml, and transcutol 0.2 g/ml. The best ItZ-ThO-SNEDDS formulation was incorporated into a honey-based gel, which demonstrated improved release of ItZ in vitro and improved transbuccal permeation ex vivo. In addition, when compared with various formulations tested in rats, the optimized loaded emulgel decreased the ulcer index. This study therefore demonstrated that the ItZ-ThO-SNEDDS could offer an effective defense against oral diseases caused by microbial infections. Taylor & Francis 2023-01-27 /pmc/articles/PMC9888461/ /pubmed/36708105 http://dx.doi.org/10.1080/10717544.2023.2173337 Text en © 2023 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Article Sindi, Amal M. Rizg, Waleed Y. Khan, Muhammad Khalid Alkhalidi, Hala M. Alharbi, Waleed S. Sabei, Fahad Y. Alfayez, Eman Alkharobi, Hanaa Korayem, Mohammed Majrashi, Mohammed Alharbi, Majed Alissa, Mohammed Safhi, Awaji Y. Jali, Abdulmajeed M. Hosny, Khaled M. Tailoring and optimization of a honey-based nanoemulgel loaded with an itraconazole–thyme oil nanoemulsion for oral candidiasis |
title | Tailoring and optimization of a honey-based nanoemulgel loaded with an itraconazole–thyme oil nanoemulsion for oral candidiasis |
title_full | Tailoring and optimization of a honey-based nanoemulgel loaded with an itraconazole–thyme oil nanoemulsion for oral candidiasis |
title_fullStr | Tailoring and optimization of a honey-based nanoemulgel loaded with an itraconazole–thyme oil nanoemulsion for oral candidiasis |
title_full_unstemmed | Tailoring and optimization of a honey-based nanoemulgel loaded with an itraconazole–thyme oil nanoemulsion for oral candidiasis |
title_short | Tailoring and optimization of a honey-based nanoemulgel loaded with an itraconazole–thyme oil nanoemulsion for oral candidiasis |
title_sort | tailoring and optimization of a honey-based nanoemulgel loaded with an itraconazole–thyme oil nanoemulsion for oral candidiasis |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9888461/ https://www.ncbi.nlm.nih.gov/pubmed/36708105 http://dx.doi.org/10.1080/10717544.2023.2173337 |
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