Comparison of chemical-induced temporomandibular osteoarthritis rat models (monosodium iodoacetate versus collagenase type II) for the study of prolonged drug delivery systems

OBJECTIVE: To compare two agents that can induce a rat model of temporomandibular joint osteoarthritis (TMJOA) by chemical induction: monosodium iodoacetate (MIA) and collagenase type 2 (Col-2). We wished to ascertain the best agent for assessing drug-delivery systems (DDSs). METHOD: Male Wistar rat...

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Detalles Bibliográficos
Autores principales: Barry, Florent, Chai, Feng, Chijcheapaza-Flores, Henry, Garcia-Fernandez, Maria José, Blanchemain, Nicolas, Nicot, Romain
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9888674/
https://www.ncbi.nlm.nih.gov/pubmed/36719872
http://dx.doi.org/10.1371/journal.pone.0281135

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