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Contribution of atrial myofiber architecture to atrial fibrillation

BACKGROUND: The role of fiber orientation on a global chamber level in sustaining atrial fibrillation (AF) is unknown. The goal of this study was to correlate the fiber direction derived from Diffusion Tensor Imaging (DTI) with AF inducibility. METHODS: Transgenic goats with cardiac-specific overexp...

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Autores principales: Kamali, Roya, Kwan, Eugene, Regouski, Misha, Bunch, T. Jared, Dosdall, Derek J., Hsu, Ed, Macleod, Rob S., Polejaeva, Irina, Ranjan, Ravi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9888724/
https://www.ncbi.nlm.nih.gov/pubmed/36719871
http://dx.doi.org/10.1371/journal.pone.0279974
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author Kamali, Roya
Kwan, Eugene
Regouski, Misha
Bunch, T. Jared
Dosdall, Derek J.
Hsu, Ed
Macleod, Rob S.
Polejaeva, Irina
Ranjan, Ravi
author_facet Kamali, Roya
Kwan, Eugene
Regouski, Misha
Bunch, T. Jared
Dosdall, Derek J.
Hsu, Ed
Macleod, Rob S.
Polejaeva, Irina
Ranjan, Ravi
author_sort Kamali, Roya
collection PubMed
description BACKGROUND: The role of fiber orientation on a global chamber level in sustaining atrial fibrillation (AF) is unknown. The goal of this study was to correlate the fiber direction derived from Diffusion Tensor Imaging (DTI) with AF inducibility. METHODS: Transgenic goats with cardiac-specific overexpression of constitutively active TGF-β1 (n = 14) underwent AF inducibility testing by rapid pacing in the left atrium. We chose a minimum of 10 minutes of sustained AF as a cut-off for AF inducibility. Explanted hearts underwent DTI to determine the fiber direction. Using tractography data, we clustered, visualized, and quantified the fiber helix angles in 8 different regions of the left atrial wall using two reference vectors defined based on anatomical landmarks. RESULTS: Sustained AF was induced in 7 out of 14 goats. The mean helix fiber angles in 7 out of 8 selected regions were statistically different (P-Value < 0.05) in the AF inducible group. The average fractional anisotropy (FA) and the mean diffusivity (MD) were similar in the two groups with FA of 0.32±0.08 and MD of 8.54±1.72 mm(2)/s in the non-inducible group and FA of 0.31±0.05 (P-value = 0.90) and MD of 8.68±1.60 mm(2)/s (P-value = 0.88) in the inducible group. CONCLUSIONS: DTI based fiber direction shows significant variability across subjects with a significant difference between animals that are AF inducible versus animals that are not inducible. Fiber direction might be contributing to the initiation and sustaining of AF, and its role needs to be investigated further.
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spelling pubmed-98887242023-02-01 Contribution of atrial myofiber architecture to atrial fibrillation Kamali, Roya Kwan, Eugene Regouski, Misha Bunch, T. Jared Dosdall, Derek J. Hsu, Ed Macleod, Rob S. Polejaeva, Irina Ranjan, Ravi PLoS One Research Article BACKGROUND: The role of fiber orientation on a global chamber level in sustaining atrial fibrillation (AF) is unknown. The goal of this study was to correlate the fiber direction derived from Diffusion Tensor Imaging (DTI) with AF inducibility. METHODS: Transgenic goats with cardiac-specific overexpression of constitutively active TGF-β1 (n = 14) underwent AF inducibility testing by rapid pacing in the left atrium. We chose a minimum of 10 minutes of sustained AF as a cut-off for AF inducibility. Explanted hearts underwent DTI to determine the fiber direction. Using tractography data, we clustered, visualized, and quantified the fiber helix angles in 8 different regions of the left atrial wall using two reference vectors defined based on anatomical landmarks. RESULTS: Sustained AF was induced in 7 out of 14 goats. The mean helix fiber angles in 7 out of 8 selected regions were statistically different (P-Value < 0.05) in the AF inducible group. The average fractional anisotropy (FA) and the mean diffusivity (MD) were similar in the two groups with FA of 0.32±0.08 and MD of 8.54±1.72 mm(2)/s in the non-inducible group and FA of 0.31±0.05 (P-value = 0.90) and MD of 8.68±1.60 mm(2)/s (P-value = 0.88) in the inducible group. CONCLUSIONS: DTI based fiber direction shows significant variability across subjects with a significant difference between animals that are AF inducible versus animals that are not inducible. Fiber direction might be contributing to the initiation and sustaining of AF, and its role needs to be investigated further. Public Library of Science 2023-01-31 /pmc/articles/PMC9888724/ /pubmed/36719871 http://dx.doi.org/10.1371/journal.pone.0279974 Text en © 2023 Kamali et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Kamali, Roya
Kwan, Eugene
Regouski, Misha
Bunch, T. Jared
Dosdall, Derek J.
Hsu, Ed
Macleod, Rob S.
Polejaeva, Irina
Ranjan, Ravi
Contribution of atrial myofiber architecture to atrial fibrillation
title Contribution of atrial myofiber architecture to atrial fibrillation
title_full Contribution of atrial myofiber architecture to atrial fibrillation
title_fullStr Contribution of atrial myofiber architecture to atrial fibrillation
title_full_unstemmed Contribution of atrial myofiber architecture to atrial fibrillation
title_short Contribution of atrial myofiber architecture to atrial fibrillation
title_sort contribution of atrial myofiber architecture to atrial fibrillation
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9888724/
https://www.ncbi.nlm.nih.gov/pubmed/36719871
http://dx.doi.org/10.1371/journal.pone.0279974
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