Peripheral administration of nanomicelle-encapsulated anti-Aβ oligomer fragment antibody reduces various toxic Aβ species in the brain

BACKGROUND: Although a large amount of evidence has revealed that amyloid β (Aβ), especially Aβ oligomers, protofibrils, and pyroglutamated Aβs, participate primarily in the pathophysiological processes of Alzheimer’s disease, most clinical trials of anti-Aβ antibody therapy have never acquired succ...

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Detalles Bibliográficos
Autores principales: Amano, Akiko, Sanjo, Nobuo, Araki, Wataru, Anraku, Yasutaka, Nakakido, Makoto, Matsubara, Etsuro, Tomiyama, Takami, Nagata, Tetsuya, Tsumoto, Kouhei, Kataoka, Kazunori, Yokota, Takanori
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9888736/
https://www.ncbi.nlm.nih.gov/pubmed/36721182
http://dx.doi.org/10.1186/s12951-023-01772-y

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