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UP165, A Standardized Corn Leaf Extract for Improving Sleep Quality and Mood State

UP165, a standardized Zea mays (corn) leaf extract, was evaluated for its effect on sleep quality and overall well-being in a double-blind, placebo-controlled clinical trial, administered orally at 250 and 500 mg/day. Participants (n = 45) (age range 19–73) consumed the supplement or placebo ∼60 min...

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Autores principales: Talbott, Shawn M., Talbott, Julie A., Brownell, Lidia, Yimam, Mesfin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Mary Ann Liebert, Inc., publishers 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9889011/
https://www.ncbi.nlm.nih.gov/pubmed/36179066
http://dx.doi.org/10.1089/jmf.2021.0197
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author Talbott, Shawn M.
Talbott, Julie A.
Brownell, Lidia
Yimam, Mesfin
author_facet Talbott, Shawn M.
Talbott, Julie A.
Brownell, Lidia
Yimam, Mesfin
author_sort Talbott, Shawn M.
collection PubMed
description UP165, a standardized Zea mays (corn) leaf extract, was evaluated for its effect on sleep quality and overall well-being in a double-blind, placebo-controlled clinical trial, administered orally at 250 and 500 mg/day. Participants (n = 45) (age range 19–73) consumed the supplement or placebo ∼60 minutes before bedtime daily for 4 weeks. Measurements that were evaluated were as follows: daily sleep quality, as monitored by a fitness tracker; the Pittsburgh Sleep Quality Index (PSQI) for sleep quality and efficiency; salivary cortisol levels for stress; and Profile of Mood States (POMS) to assess general well-being. Participants who received UP165 showed a statistically significant and dose-correlated reduction in salivary cortisol (up to 36%); an increase in deep sleep time (up to 30 minutes); increased total sleep time (up to 10%); an improvement in sleep quality (up to 49%), and an enhanced POMS (36–58%). Participants in the UP165 group showed a sevenfold increase in deep sleep time and a 10-fold increase in PSQI sleep quality improvement compared to placebo. Collectively, UP165 is a safe nutritional supplement clinically proven for a 24-hour support with better quality and efficiency of sleep at night and an improved mood state and overall well-being during the day. The clinical study has been ISRCTN registered with study ID ISRCTN68282897.
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spelling pubmed-98890112023-02-01 UP165, A Standardized Corn Leaf Extract for Improving Sleep Quality and Mood State Talbott, Shawn M. Talbott, Julie A. Brownell, Lidia Yimam, Mesfin J Med Food Full Communications UP165, a standardized Zea mays (corn) leaf extract, was evaluated for its effect on sleep quality and overall well-being in a double-blind, placebo-controlled clinical trial, administered orally at 250 and 500 mg/day. Participants (n = 45) (age range 19–73) consumed the supplement or placebo ∼60 minutes before bedtime daily for 4 weeks. Measurements that were evaluated were as follows: daily sleep quality, as monitored by a fitness tracker; the Pittsburgh Sleep Quality Index (PSQI) for sleep quality and efficiency; salivary cortisol levels for stress; and Profile of Mood States (POMS) to assess general well-being. Participants who received UP165 showed a statistically significant and dose-correlated reduction in salivary cortisol (up to 36%); an increase in deep sleep time (up to 30 minutes); increased total sleep time (up to 10%); an improvement in sleep quality (up to 49%), and an enhanced POMS (36–58%). Participants in the UP165 group showed a sevenfold increase in deep sleep time and a 10-fold increase in PSQI sleep quality improvement compared to placebo. Collectively, UP165 is a safe nutritional supplement clinically proven for a 24-hour support with better quality and efficiency of sleep at night and an improved mood state and overall well-being during the day. The clinical study has been ISRCTN registered with study ID ISRCTN68282897. Mary Ann Liebert, Inc., publishers 2023-01-01 2023-01-12 /pmc/articles/PMC9889011/ /pubmed/36179066 http://dx.doi.org/10.1089/jmf.2021.0197 Text en © Shawn M. Talbott et al. 2023; Published by Mary Ann Liebert, Inc. https://creativecommons.org/licenses/by/4.0/This Open Access article is distributed under the terms of the Creative Commons License [CC-BY] (http://creativecommons.org/licenses/by/4.0 (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Full Communications
Talbott, Shawn M.
Talbott, Julie A.
Brownell, Lidia
Yimam, Mesfin
UP165, A Standardized Corn Leaf Extract for Improving Sleep Quality and Mood State
title UP165, A Standardized Corn Leaf Extract for Improving Sleep Quality and Mood State
title_full UP165, A Standardized Corn Leaf Extract for Improving Sleep Quality and Mood State
title_fullStr UP165, A Standardized Corn Leaf Extract for Improving Sleep Quality and Mood State
title_full_unstemmed UP165, A Standardized Corn Leaf Extract for Improving Sleep Quality and Mood State
title_short UP165, A Standardized Corn Leaf Extract for Improving Sleep Quality and Mood State
title_sort up165, a standardized corn leaf extract for improving sleep quality and mood state
topic Full Communications
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9889011/
https://www.ncbi.nlm.nih.gov/pubmed/36179066
http://dx.doi.org/10.1089/jmf.2021.0197
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