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Folylpolyglutamate synthetase mRNA G-quadruplexes regulate its cell protrusion localization and enhance a cancer cell invasive phenotype upon folate repletion

BACKGROUND: Folates are crucial for the biosynthesis of nucleotides and amino acids, essential for cell proliferation and development. Folate deficiency induces DNA damage, developmental defects, and tumorigenicity. The obligatory enzyme folylpolyglutamate synthetase (FPGS) mediates intracellular fo...

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Detalles Bibliográficos
Autores principales:	Stark, Michal, Levin, May, Ulitsky, Igor, Assaraf, Yehuda G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9889130/ https://www.ncbi.nlm.nih.gov/pubmed/36721160 http://dx.doi.org/10.1186/s12915-023-01525-1

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