Tailored Treatment Based on Helicobacter pylori Genetic Markers of Resistance Is Associated With Higher Eradication Success

Increasing antimicrobial resistance with Helicobacter pylori infection has focused efforts to tailor eradication therapy based on identifying genetic markers of resistance to predict antimicrobial susceptibility. METHODS: In this retrospective study, we report the effect of routine inclusion of anti...

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Autores principales: Cummings, Linda C., Hojat, Leila S., Nguyen, David C., Stempak, Lisa M., Rhoads, Daniel D., Sadri, Navid
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer 2023
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9889191/
https://www.ncbi.nlm.nih.gov/pubmed/36574274
http://dx.doi.org/10.14309/ajg.0000000000002085
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author Cummings, Linda C.
Hojat, Leila S.
Nguyen, David C.
Stempak, Lisa M.
Rhoads, Daniel D.
Sadri, Navid
author_facet Cummings, Linda C.
Hojat, Leila S.
Nguyen, David C.
Stempak, Lisa M.
Rhoads, Daniel D.
Sadri, Navid
author_sort Cummings, Linda C.
collection PubMed
description Increasing antimicrobial resistance with Helicobacter pylori infection has focused efforts to tailor eradication therapy based on identifying genetic markers of resistance to predict antimicrobial susceptibility. METHODS: In this retrospective study, we report the effect of routine inclusion of antimicrobial susceptibility testing and recommendations for eradication therapy with gastric specimens with H. pylori. RESULTS: The use of a recommended treatment regimen based on genetic markers of resistance was associated with an 84% rate of eradication success and 4.4 greater odds of eradication relative to unrecommended treatment. DISCUSSION: This is the first study describing the use of H. pylori genetic resistance testing as standard of care.
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spelling pubmed-98891912023-02-07 Tailored Treatment Based on Helicobacter pylori Genetic Markers of Resistance Is Associated With Higher Eradication Success Cummings, Linda C. Hojat, Leila S. Nguyen, David C. Stempak, Lisa M. Rhoads, Daniel D. Sadri, Navid Am J Gastroenterol Brief Communication Increasing antimicrobial resistance with Helicobacter pylori infection has focused efforts to tailor eradication therapy based on identifying genetic markers of resistance to predict antimicrobial susceptibility. METHODS: In this retrospective study, we report the effect of routine inclusion of antimicrobial susceptibility testing and recommendations for eradication therapy with gastric specimens with H. pylori. RESULTS: The use of a recommended treatment regimen based on genetic markers of resistance was associated with an 84% rate of eradication success and 4.4 greater odds of eradication relative to unrecommended treatment. DISCUSSION: This is the first study describing the use of H. pylori genetic resistance testing as standard of care. Wolters Kluwer 2023-02 2022-10-11 /pmc/articles/PMC9889191/ /pubmed/36574274 http://dx.doi.org/10.14309/ajg.0000000000002085 Text en Copyright © 2022 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of The American College of Gastroenterology https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND) (https://creativecommons.org/licenses/by-nc-nd/4.0/) , where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.
spellingShingle Brief Communication
Cummings, Linda C.
Hojat, Leila S.
Nguyen, David C.
Stempak, Lisa M.
Rhoads, Daniel D.
Sadri, Navid
Tailored Treatment Based on Helicobacter pylori Genetic Markers of Resistance Is Associated With Higher Eradication Success
title Tailored Treatment Based on Helicobacter pylori Genetic Markers of Resistance Is Associated With Higher Eradication Success
title_full Tailored Treatment Based on Helicobacter pylori Genetic Markers of Resistance Is Associated With Higher Eradication Success
title_fullStr Tailored Treatment Based on Helicobacter pylori Genetic Markers of Resistance Is Associated With Higher Eradication Success
title_full_unstemmed Tailored Treatment Based on Helicobacter pylori Genetic Markers of Resistance Is Associated With Higher Eradication Success
title_short Tailored Treatment Based on Helicobacter pylori Genetic Markers of Resistance Is Associated With Higher Eradication Success
title_sort tailored treatment based on helicobacter pylori genetic markers of resistance is associated with higher eradication success
topic Brief Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9889191/
https://www.ncbi.nlm.nih.gov/pubmed/36574274
http://dx.doi.org/10.14309/ajg.0000000000002085
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