A small erythropoietin derived non-hematopoietic peptide reduces cardiac inflammation, attenuates age associated declines in heart function and prolongs healthspan

BACKGROUND: Aging is associated with increased levels of reactive oxygen species and inflammation that disrupt proteostasis and mitochondrial function and leads to organism-wide frailty later in life. ARA290 (cibinetide), an 11-aa non-hematopoietic peptide sequence within the cardioprotective domain...

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Detalles Bibliográficos
Autores principales: Winicki, Nolan M., Nanavati, Alay P., Morrell, Christopher H., Moen, Jack M., Axsom, Jessie E., Krawczyk, Melissa, Petrashevskaya, Natalia N., Beyman, Max G., Ramirez, Christopher, Alfaras, Irene, Mitchell, Sarah J., Juhaszova, Magdalena, Riordon, Daniel R., Wang, Mingyi, Zhang, Jing, Cerami, Anthony, Brines, Michael, Sollott, Steven J., de Cabo, Rafael, Lakatta, Edward G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Cardiovascular Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9889362/
https://www.ncbi.nlm.nih.gov/pubmed/36741836
http://dx.doi.org/10.3389/fcvm.2022.1096887

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