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Gut microbiota-derived metabolites and their importance in neurological disorders

Microbial-derived metabolites are the intermediate or end products of bacterial digestion. They are one of the most important molecules for the gut to connect with the brain. Depending on the levels of specific metabolites produced in the host, it can exert beneficial or detrimental effects on the b...

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Autores principales: Swer, Nicole Mary, Venkidesh, B S, Murali, Thokur Sreepathy, Mumbrekar, Kamalesh Dattaram
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Netherlands 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9889412/
https://www.ncbi.nlm.nih.gov/pubmed/36399245
http://dx.doi.org/10.1007/s11033-022-08038-0
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author Swer, Nicole Mary
Venkidesh, B S
Murali, Thokur Sreepathy
Mumbrekar, Kamalesh Dattaram
author_facet Swer, Nicole Mary
Venkidesh, B S
Murali, Thokur Sreepathy
Mumbrekar, Kamalesh Dattaram
author_sort Swer, Nicole Mary
collection PubMed
description Microbial-derived metabolites are the intermediate or end products of bacterial digestion. They are one of the most important molecules for the gut to connect with the brain. Depending on the levels of specific metabolites produced in the host, it can exert beneficial or detrimental effects on the brain and have been linked to several neurodegenerative and neuropsychiatric disorders. However, the underlying mechanisms remain largely unexplored. Insight into these mechanisms could reveal new pathways or targets, resulting in novel treatment approaches targeting neurodegenerative diseases. We have reviewed selected metabolites, including short-chain fatty acids, aromatic amino acids, trimethylamine-N-oxide,  urolithin A, anthocyanins, equols, imidazole, and propionate to highlight their mechanism of action, underlying role in maintaining intestinal homeostasis and regulating neuro-immunoendocrine function. Further discussed on  how altered metabolite levels can influence the gut–brain axis could lead to new prevention strategies or novel treatment approaches to neural disorders.
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spelling pubmed-98894122023-02-02 Gut microbiota-derived metabolites and their importance in neurological disorders Swer, Nicole Mary Venkidesh, B S Murali, Thokur Sreepathy Mumbrekar, Kamalesh Dattaram Mol Biol Rep Review Microbial-derived metabolites are the intermediate or end products of bacterial digestion. They are one of the most important molecules for the gut to connect with the brain. Depending on the levels of specific metabolites produced in the host, it can exert beneficial or detrimental effects on the brain and have been linked to several neurodegenerative and neuropsychiatric disorders. However, the underlying mechanisms remain largely unexplored. Insight into these mechanisms could reveal new pathways or targets, resulting in novel treatment approaches targeting neurodegenerative diseases. We have reviewed selected metabolites, including short-chain fatty acids, aromatic amino acids, trimethylamine-N-oxide,  urolithin A, anthocyanins, equols, imidazole, and propionate to highlight their mechanism of action, underlying role in maintaining intestinal homeostasis and regulating neuro-immunoendocrine function. Further discussed on  how altered metabolite levels can influence the gut–brain axis could lead to new prevention strategies or novel treatment approaches to neural disorders. Springer Netherlands 2022-11-18 2023 /pmc/articles/PMC9889412/ /pubmed/36399245 http://dx.doi.org/10.1007/s11033-022-08038-0 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review
Swer, Nicole Mary
Venkidesh, B S
Murali, Thokur Sreepathy
Mumbrekar, Kamalesh Dattaram
Gut microbiota-derived metabolites and their importance in neurological disorders
title Gut microbiota-derived metabolites and their importance in neurological disorders
title_full Gut microbiota-derived metabolites and their importance in neurological disorders
title_fullStr Gut microbiota-derived metabolites and their importance in neurological disorders
title_full_unstemmed Gut microbiota-derived metabolites and their importance in neurological disorders
title_short Gut microbiota-derived metabolites and their importance in neurological disorders
title_sort gut microbiota-derived metabolites and their importance in neurological disorders
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9889412/
https://www.ncbi.nlm.nih.gov/pubmed/36399245
http://dx.doi.org/10.1007/s11033-022-08038-0
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