Cargando…
The comparison of risk factors for colorectal neoplasms at different anatomical sites
AIM: Both the clinical manifestation and molecular characteristics of colorectal cancer (CRC) vary according to the anatomical site. We explored the risk factors for four groups of colorectal neoplasms (CRN) at different anatomical sites. METHODS: We extracted data from the database of Tianjin Color...
Autores principales: | , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Berlin Heidelberg
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9889414/ https://www.ncbi.nlm.nih.gov/pubmed/36719544 http://dx.doi.org/10.1007/s00384-022-04296-3 |
_version_ | 1784880724206157824 |
---|---|
author | Wang, Huaqing Yuan, Zhen Wang, Shuyuan Pang, Wenwen Wang, Wanting Liu, Xinyu Yi, Ben Han, Qiurong Yao, Yao Zhang, Qinghuai Zhang, Xipeng Zhang, Chunze |
author_facet | Wang, Huaqing Yuan, Zhen Wang, Shuyuan Pang, Wenwen Wang, Wanting Liu, Xinyu Yi, Ben Han, Qiurong Yao, Yao Zhang, Qinghuai Zhang, Xipeng Zhang, Chunze |
author_sort | Wang, Huaqing |
collection | PubMed |
description | AIM: Both the clinical manifestation and molecular characteristics of colorectal cancer (CRC) vary according to the anatomical site. We explored the risk factors for four groups of colorectal neoplasms (CRN) at different anatomical sites. METHODS: We extracted data from the database of Tianjin Colorectal Cancer Screening Program from 2010 to 2020. According to the CRN anatomical sites, patients were divided into four groups: the proximal colon group, the distal colon group, the rectum group, and the multiple colorectal sites. Binary logistic regression analysis was used to explore the differences in risk factors of CRN at different anatomical sites. RESULTS: The numbers of patients with CRN in the proximal colon, distal colon, rectum, and multiple colorectal sites were 4023, 6920, 3657, and 7938, respectively. Male sex was associated with a higher risk from the proximal colon to the rectum. Advanced age and obesity were also significantly associated with overall colorectal CRN risk, but there were some differences between men and women. Smoking was associated with CRN risk only in the distal colon and rectum in both men and women. Frequent alcohol consumption and family history of CRC in first-degree relatives (FDRs) were associated with the risk of multisite colorectal CRN only in males. CONCLUSIONS: We observed differences in advanced age, obesity, smoking, alcohol consumption, and family history of colorectal cancer at different anatomical sites of colorectal neoplasms. These factors vary by gender. |
format | Online Article Text |
id | pubmed-9889414 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Springer Berlin Heidelberg |
record_format | MEDLINE/PubMed |
spelling | pubmed-98894142023-02-02 The comparison of risk factors for colorectal neoplasms at different anatomical sites Wang, Huaqing Yuan, Zhen Wang, Shuyuan Pang, Wenwen Wang, Wanting Liu, Xinyu Yi, Ben Han, Qiurong Yao, Yao Zhang, Qinghuai Zhang, Xipeng Zhang, Chunze Int J Colorectal Dis Research AIM: Both the clinical manifestation and molecular characteristics of colorectal cancer (CRC) vary according to the anatomical site. We explored the risk factors for four groups of colorectal neoplasms (CRN) at different anatomical sites. METHODS: We extracted data from the database of Tianjin Colorectal Cancer Screening Program from 2010 to 2020. According to the CRN anatomical sites, patients were divided into four groups: the proximal colon group, the distal colon group, the rectum group, and the multiple colorectal sites. Binary logistic regression analysis was used to explore the differences in risk factors of CRN at different anatomical sites. RESULTS: The numbers of patients with CRN in the proximal colon, distal colon, rectum, and multiple colorectal sites were 4023, 6920, 3657, and 7938, respectively. Male sex was associated with a higher risk from the proximal colon to the rectum. Advanced age and obesity were also significantly associated with overall colorectal CRN risk, but there were some differences between men and women. Smoking was associated with CRN risk only in the distal colon and rectum in both men and women. Frequent alcohol consumption and family history of CRC in first-degree relatives (FDRs) were associated with the risk of multisite colorectal CRN only in males. CONCLUSIONS: We observed differences in advanced age, obesity, smoking, alcohol consumption, and family history of colorectal cancer at different anatomical sites of colorectal neoplasms. These factors vary by gender. Springer Berlin Heidelberg 2023-01-31 2023 /pmc/articles/PMC9889414/ /pubmed/36719544 http://dx.doi.org/10.1007/s00384-022-04296-3 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Research Wang, Huaqing Yuan, Zhen Wang, Shuyuan Pang, Wenwen Wang, Wanting Liu, Xinyu Yi, Ben Han, Qiurong Yao, Yao Zhang, Qinghuai Zhang, Xipeng Zhang, Chunze The comparison of risk factors for colorectal neoplasms at different anatomical sites |
title | The comparison of risk factors for colorectal neoplasms at different anatomical sites |
title_full | The comparison of risk factors for colorectal neoplasms at different anatomical sites |
title_fullStr | The comparison of risk factors for colorectal neoplasms at different anatomical sites |
title_full_unstemmed | The comparison of risk factors for colorectal neoplasms at different anatomical sites |
title_short | The comparison of risk factors for colorectal neoplasms at different anatomical sites |
title_sort | comparison of risk factors for colorectal neoplasms at different anatomical sites |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9889414/ https://www.ncbi.nlm.nih.gov/pubmed/36719544 http://dx.doi.org/10.1007/s00384-022-04296-3 |
work_keys_str_mv | AT wanghuaqing thecomparisonofriskfactorsforcolorectalneoplasmsatdifferentanatomicalsites AT yuanzhen thecomparisonofriskfactorsforcolorectalneoplasmsatdifferentanatomicalsites AT wangshuyuan thecomparisonofriskfactorsforcolorectalneoplasmsatdifferentanatomicalsites AT pangwenwen thecomparisonofriskfactorsforcolorectalneoplasmsatdifferentanatomicalsites AT wangwanting thecomparisonofriskfactorsforcolorectalneoplasmsatdifferentanatomicalsites AT liuxinyu thecomparisonofriskfactorsforcolorectalneoplasmsatdifferentanatomicalsites AT yiben thecomparisonofriskfactorsforcolorectalneoplasmsatdifferentanatomicalsites AT hanqiurong thecomparisonofriskfactorsforcolorectalneoplasmsatdifferentanatomicalsites AT yaoyao thecomparisonofriskfactorsforcolorectalneoplasmsatdifferentanatomicalsites AT zhangqinghuai thecomparisonofriskfactorsforcolorectalneoplasmsatdifferentanatomicalsites AT zhangxipeng thecomparisonofriskfactorsforcolorectalneoplasmsatdifferentanatomicalsites AT zhangchunze thecomparisonofriskfactorsforcolorectalneoplasmsatdifferentanatomicalsites AT wanghuaqing comparisonofriskfactorsforcolorectalneoplasmsatdifferentanatomicalsites AT yuanzhen comparisonofriskfactorsforcolorectalneoplasmsatdifferentanatomicalsites AT wangshuyuan comparisonofriskfactorsforcolorectalneoplasmsatdifferentanatomicalsites AT pangwenwen comparisonofriskfactorsforcolorectalneoplasmsatdifferentanatomicalsites AT wangwanting comparisonofriskfactorsforcolorectalneoplasmsatdifferentanatomicalsites AT liuxinyu comparisonofriskfactorsforcolorectalneoplasmsatdifferentanatomicalsites AT yiben comparisonofriskfactorsforcolorectalneoplasmsatdifferentanatomicalsites AT hanqiurong comparisonofriskfactorsforcolorectalneoplasmsatdifferentanatomicalsites AT yaoyao comparisonofriskfactorsforcolorectalneoplasmsatdifferentanatomicalsites AT zhangqinghuai comparisonofriskfactorsforcolorectalneoplasmsatdifferentanatomicalsites AT zhangxipeng comparisonofriskfactorsforcolorectalneoplasmsatdifferentanatomicalsites AT zhangchunze comparisonofriskfactorsforcolorectalneoplasmsatdifferentanatomicalsites |