Free-breathing cardiovascular cine magnetic resonance imaging using compressed-sensing and retrospective motion correction: accurate assessment of biventricular volume at 3T

PURPOSE: We applied a combination of compressed-sensing (CS) and retrospective motion correction to free-breathing cine magnetic resonance (MR) (FBCS cine MoCo). We validated FBCS cine MoCo by comparing it with breath-hold (BH) conventional cine MR. MATERIALS AND METHODS: Thirty-five volunteers underwent both FBCS cine MoCo and BH conventional cine MR imaging. Twelve consecutive short-axis cine images were obtained. We compared the examination time, image quality and biventricular volumetric assessments between the two cine MR. RESULTS: FBCS cine MoCo required a significantly shorter examination time than BH conventional cine (135 s [110–143 s] vs. 198 s [186–349 s], p < 0.001). The image quality scores were not significantly different between the two techniques (End-diastole: FBCS cine MoCo; 4.7 ± 0.5 vs. BH conventional cine; 4.6 ± 0.6; p = 0.77, End-systole: FBCS cine MoCo; 4.5 ± 0.5 vs. BH conventional cine; 4.5 ± 0.6; p = 0.52). No significant differences were observed in all biventricular volumetric assessments between the two techniques. The mean differences with 95% confidence interval (CI), based on Bland–Altman analysis, were − 0.3 mL (− 8.2 − 7.5 mL) for LVEDV, 0.2 mL (− 5.6 − 5.9 mL) for LVESV, − 0.5 mL (− 6.3 − 5.2 mL) for LVSV, − 0.3% (− 3.5 − 3.0%) for LVEF, − 0.1 g (− 8.5 − 8.3 g) for LVED mass, 1.4 mL (− 15.5 − 18.3 mL) for RVEDV, 2.1 mL (− 11.2 − 15.3 mL) for RVESV, − 0.6 mL (− 9.7 − 8.4 mL) for RVSV, − 1.0% (− 6.5 − 4.6%) for RVEF. CONCLUSION: FBCS cine MoCo can potentially replace multiple BH conventional cine MR and improve the clinical utility of cine MR.