Gp130 is expressed in pancreatic cancer and can be targeted by the small inhibitor molecule SC144

PURPOSE: Interleukin 6 (IL-6), Oncostatin M (OSM), and downstream effector STAT3 are pro-tumorigenic agents in pancreatic ductal adenocarcinoma (PDAC). Glycoprotein 130 (gp130) is a compound of the IL-6 and OSM receptor complex that triggers STAT3 signaling. SC144 is a small molecule gp130 inhibitor...

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Detalles Bibliográficos
Autores principales: Pozios, Ioannis, Hering, Nina A., Guenzler, Emily, Arndt, Marco, Elezkurtaj, Sefer, Knösel, Thomas, Bruns, Christiane J., Margonis, Georgios A., Beyer, Katharina, Seeliger, Hendrik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9889481/
https://www.ncbi.nlm.nih.gov/pubmed/36495330
http://dx.doi.org/10.1007/s00432-022-04518-9

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