Estrogen fluctuations during the menopausal transition are a risk factor for depressive disorders

Women are significantly more likely to develop depression than men. Fluctuations in the ovarian estrogen hormone levels are closely linked with women's well-being. This narrative review discusses the available knowledge on the role of estrogen in modulating brain function and the correlation be...

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Detalles Bibliográficos
Autores principales: Turek, Justyna, Gąsior, Łukasz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9889489/
https://www.ncbi.nlm.nih.gov/pubmed/36639604
http://dx.doi.org/10.1007/s43440-022-00444-2
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author Turek, Justyna
Gąsior, Łukasz
author_facet Turek, Justyna
Gąsior, Łukasz
author_sort Turek, Justyna
collection PubMed
description Women are significantly more likely to develop depression than men. Fluctuations in the ovarian estrogen hormone levels are closely linked with women's well-being. This narrative review discusses the available knowledge on the role of estrogen in modulating brain function and the correlation between changes in estrogen levels and the development of depression. Equally discussed are the possible mechanisms underlying these effects, including the role of estrogen in modulating brain-derived neurotrophic factor activity, serotonin neurotransmission, as well as the induction of inflammatory response and changes in metabolic activity, are discussed.
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spelling pubmed-98894892023-02-02 Estrogen fluctuations during the menopausal transition are a risk factor for depressive disorders Turek, Justyna Gąsior, Łukasz Pharmacol Rep Review Women are significantly more likely to develop depression than men. Fluctuations in the ovarian estrogen hormone levels are closely linked with women's well-being. This narrative review discusses the available knowledge on the role of estrogen in modulating brain function and the correlation between changes in estrogen levels and the development of depression. Equally discussed are the possible mechanisms underlying these effects, including the role of estrogen in modulating brain-derived neurotrophic factor activity, serotonin neurotransmission, as well as the induction of inflammatory response and changes in metabolic activity, are discussed. Springer International Publishing 2023-01-14 2023 /pmc/articles/PMC9889489/ /pubmed/36639604 http://dx.doi.org/10.1007/s43440-022-00444-2 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review
Turek, Justyna
Gąsior, Łukasz
Estrogen fluctuations during the menopausal transition are a risk factor for depressive disorders
title Estrogen fluctuations during the menopausal transition are a risk factor for depressive disorders
title_full Estrogen fluctuations during the menopausal transition are a risk factor for depressive disorders
title_fullStr Estrogen fluctuations during the menopausal transition are a risk factor for depressive disorders
title_full_unstemmed Estrogen fluctuations during the menopausal transition are a risk factor for depressive disorders
title_short Estrogen fluctuations during the menopausal transition are a risk factor for depressive disorders
title_sort estrogen fluctuations during the menopausal transition are a risk factor for depressive disorders
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9889489/
https://www.ncbi.nlm.nih.gov/pubmed/36639604
http://dx.doi.org/10.1007/s43440-022-00444-2
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