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Molecular and pathobiological insights of bikunin/UTI in cancer
Bikunin is a small chondroitin sulfate proteoglycan (PG) with Ser-protease inhibitory activity that plays pleiotropic roles in health and disease. It is involved in several physiological processes including stabilization of the extracellular matrix (ECM) of connective tissues and key reproductive ev...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Netherlands
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9889512/ https://www.ncbi.nlm.nih.gov/pubmed/36414878 http://dx.doi.org/10.1007/s11033-022-08117-2 |
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author | Lepedda, Antonio Junior Nieddu, Gabriele Cannas, Claudia Formato, Marilena |
author_facet | Lepedda, Antonio Junior Nieddu, Gabriele Cannas, Claudia Formato, Marilena |
author_sort | Lepedda, Antonio Junior |
collection | PubMed |
description | Bikunin is a small chondroitin sulfate proteoglycan (PG) with Ser-protease inhibitory activity that plays pleiotropic roles in health and disease. It is involved in several physiological processes including stabilization of the extracellular matrix (ECM) of connective tissues and key reproductive events. Bikunin is also implicated in both acute and chronic inflammatory conditions and represents a non-invasive circulating and/or urinary (as Urinary Trypsin Inhibitor or UTI) biomarker. It exerts inhibitory effects on urokinase-type plasminogen activator (uPA) and its receptor (uPAR) mediating tumor invasiveness by a down-regulation of uPA mRNA expression, thus representing an anti-metastatic agent. However, only limited data on its potential as a diagnostic and/or prognostic marker of cancer have been reported so far. Recent technological advances in mass spectrometry-based proteomics have provided researchers with a huge amount of information allowing for large-scale surveys of the cancer proteome. To address such issues, we analyzed bikunin expression data across several types of tumors, by using UALCAN proteogenomic analysis portal. In this article we critically review the roles of bikunin in human pathobiology, with a special focus on its inhibitory effects and mechanisms in cancer aggressiveness as well as its significance as cancer circulating biomarker. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s11033-022-08117-2. |
format | Online Article Text |
id | pubmed-9889512 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Springer Netherlands |
record_format | MEDLINE/PubMed |
spelling | pubmed-98895122023-02-02 Molecular and pathobiological insights of bikunin/UTI in cancer Lepedda, Antonio Junior Nieddu, Gabriele Cannas, Claudia Formato, Marilena Mol Biol Rep Review Bikunin is a small chondroitin sulfate proteoglycan (PG) with Ser-protease inhibitory activity that plays pleiotropic roles in health and disease. It is involved in several physiological processes including stabilization of the extracellular matrix (ECM) of connective tissues and key reproductive events. Bikunin is also implicated in both acute and chronic inflammatory conditions and represents a non-invasive circulating and/or urinary (as Urinary Trypsin Inhibitor or UTI) biomarker. It exerts inhibitory effects on urokinase-type plasminogen activator (uPA) and its receptor (uPAR) mediating tumor invasiveness by a down-regulation of uPA mRNA expression, thus representing an anti-metastatic agent. However, only limited data on its potential as a diagnostic and/or prognostic marker of cancer have been reported so far. Recent technological advances in mass spectrometry-based proteomics have provided researchers with a huge amount of information allowing for large-scale surveys of the cancer proteome. To address such issues, we analyzed bikunin expression data across several types of tumors, by using UALCAN proteogenomic analysis portal. In this article we critically review the roles of bikunin in human pathobiology, with a special focus on its inhibitory effects and mechanisms in cancer aggressiveness as well as its significance as cancer circulating biomarker. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s11033-022-08117-2. Springer Netherlands 2022-11-21 2023 /pmc/articles/PMC9889512/ /pubmed/36414878 http://dx.doi.org/10.1007/s11033-022-08117-2 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Review Lepedda, Antonio Junior Nieddu, Gabriele Cannas, Claudia Formato, Marilena Molecular and pathobiological insights of bikunin/UTI in cancer |
title | Molecular and pathobiological insights of bikunin/UTI in cancer |
title_full | Molecular and pathobiological insights of bikunin/UTI in cancer |
title_fullStr | Molecular and pathobiological insights of bikunin/UTI in cancer |
title_full_unstemmed | Molecular and pathobiological insights of bikunin/UTI in cancer |
title_short | Molecular and pathobiological insights of bikunin/UTI in cancer |
title_sort | molecular and pathobiological insights of bikunin/uti in cancer |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9889512/ https://www.ncbi.nlm.nih.gov/pubmed/36414878 http://dx.doi.org/10.1007/s11033-022-08117-2 |
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