The mechanism of NLRP3 inflammasome activation and its pharmacological inhibitors

NLRP3 (NOD-, LRR-, and pyrin domain-containing protein 3) is a cytosolic pattern recognition receptor (PRR) that recognizes multiple pathogen-associated molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs). Once activated, NLRP3 initiates the inflammasome assembly together wit...

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Autores principales: Zhan, Xiaoyan, Li, Qiang, Xu, Guang, Xiao, Xiaohe, Bai, Zhaofang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9889537/
https://www.ncbi.nlm.nih.gov/pubmed/36741414
http://dx.doi.org/10.3389/fimmu.2022.1109938
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author Zhan, Xiaoyan
Li, Qiang
Xu, Guang
Xiao, Xiaohe
Bai, Zhaofang
author_facet Zhan, Xiaoyan
Li, Qiang
Xu, Guang
Xiao, Xiaohe
Bai, Zhaofang
author_sort Zhan, Xiaoyan
collection PubMed
description NLRP3 (NOD-, LRR-, and pyrin domain-containing protein 3) is a cytosolic pattern recognition receptor (PRR) that recognizes multiple pathogen-associated molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs). Once activated, NLRP3 initiates the inflammasome assembly together with the adaptor ASC and the effector caspase-1, leading to caspase-1 activation and subsequent cleavage of IL-1β and IL-18. Aberrant NLRP3 inflammasome activation is linked with the pathogenesis of multiple inflammatory diseases, such as cryopyrin­associated periodic syndromes, type 2 diabetes, non-alcoholic steatohepatitis, gout, and neurodegenerative diseases. Thus, NLRP3 is an important therapeutic target, and researchers are putting a lot of effort into developing its inhibitors. The review summarizes the latest advances in the mechanism of NLRP3 inflammasome activation and its pharmacological inhibitors.
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spelling pubmed-98895372023-02-02 The mechanism of NLRP3 inflammasome activation and its pharmacological inhibitors Zhan, Xiaoyan Li, Qiang Xu, Guang Xiao, Xiaohe Bai, Zhaofang Front Immunol Immunology NLRP3 (NOD-, LRR-, and pyrin domain-containing protein 3) is a cytosolic pattern recognition receptor (PRR) that recognizes multiple pathogen-associated molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs). Once activated, NLRP3 initiates the inflammasome assembly together with the adaptor ASC and the effector caspase-1, leading to caspase-1 activation and subsequent cleavage of IL-1β and IL-18. Aberrant NLRP3 inflammasome activation is linked with the pathogenesis of multiple inflammatory diseases, such as cryopyrin­associated periodic syndromes, type 2 diabetes, non-alcoholic steatohepatitis, gout, and neurodegenerative diseases. Thus, NLRP3 is an important therapeutic target, and researchers are putting a lot of effort into developing its inhibitors. The review summarizes the latest advances in the mechanism of NLRP3 inflammasome activation and its pharmacological inhibitors. Frontiers Media S.A. 2023-01-18 /pmc/articles/PMC9889537/ /pubmed/36741414 http://dx.doi.org/10.3389/fimmu.2022.1109938 Text en Copyright © 2023 Zhan, Li, Xu, Xiao and Bai https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Zhan, Xiaoyan
Li, Qiang
Xu, Guang
Xiao, Xiaohe
Bai, Zhaofang
The mechanism of NLRP3 inflammasome activation and its pharmacological inhibitors
title The mechanism of NLRP3 inflammasome activation and its pharmacological inhibitors
title_full The mechanism of NLRP3 inflammasome activation and its pharmacological inhibitors
title_fullStr The mechanism of NLRP3 inflammasome activation and its pharmacological inhibitors
title_full_unstemmed The mechanism of NLRP3 inflammasome activation and its pharmacological inhibitors
title_short The mechanism of NLRP3 inflammasome activation and its pharmacological inhibitors
title_sort mechanism of nlrp3 inflammasome activation and its pharmacological inhibitors
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9889537/
https://www.ncbi.nlm.nih.gov/pubmed/36741414
http://dx.doi.org/10.3389/fimmu.2022.1109938
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