Cargando…

Pirfenidone suppressed triple‐negative breast cancer metastasis by inhibiting the activity of the TGF‐β/SMAD pathway

Among breast cancer patients, metastases are the leading cause of death. Despite decades of effort, little progress has been made to improve the treatment of breast cancer metastases, especially triple‐negative breast cancer (TNBC). The extracellular matrix plays an important role in tumour growth a...

Descripción completa

Detalles Bibliográficos
Autores principales:	Luo, Daiqin, Zeng, Xianlin, Zhang, Shuling, Li, Daohong, Cheng, Zhimei, Wang, Yun, Long, Jinhua, Hu, Zuquan, Long, Shiqi, Zhou, Jing, Zhang, Shuai, Zeng, Zhu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2023
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9889661/ https://www.ncbi.nlm.nih.gov/pubmed/36651490 http://dx.doi.org/10.1111/jcmm.17673

Ejemplares similares

Pirfenidone Alleviates Choroidal Neovascular Fibrosis through TGF-β/Smad Signaling Pathway
por: Gao, Chuang, et al.
Publicado: (2021)

Loss of RAB1B promotes triple-negative breast cancer metastasis by activating TGF-β/SMAD signaling
por: Jiang, Hong-Lin, et al.
Publicado: (2015)

Inhibition of TGF-β2–Induced Trabecular Meshwork Fibrosis by Pirfenidone
por: Zhu, Xiaofeng, et al.
Publicado: (2023)

Investigating the effects of Pirfenidone on TGF-β1 stimulated non-SMAD signaling pathways in Dupuytren’s disease -derived fibroblasts
por: Zhou, Chaoming, et al.
Publicado: (2019)

Combination of CTLA-4 blockade with MUC1 mRNA nanovaccine induces enhanced anti-tumor CTL activity by modulating tumor microenvironment of triple negative breast cancer
por: Lin, Xuan, et al.
Publicado: (2021)

Pirfenidone modulates macrophage polarization and ameliorates radiation‐induced lung fibrosis by inhibiting the TGF‐β1/Smad3 pathway
por: Ying, Hangjie, et al.
Publicado: (2021)

Pirfenidone alleviates cardiac fibrosis induced by pressure overload via inhibiting TGF‐β1/Smad3 signalling pathway
por: Li, Na, et al.
Publicado: (2022)

MicroRNA-362 negatively and positively regulates SMAD4 expression in TGF-β/SMAD signaling to suppress cell migration and invasion
por: Cheng, Han Ping, et al.
Publicado: (2021)

Development of an Immunogenomic Landscape-Based Prognostic Index of Head and Neck Squamous Cell Carcinoma
por: Long, Jinhua, et al.
Publicado: (2020)

Pirfenidone suppresses TGF-β1-induced human intestinal fibroblasts activities by regulating proliferation and apoptosis via the inhibition of the Smad and PI3K/AKT signaling pathway
por: Sun, Yanwu, et al.
Publicado: (2018)

The regulation of TGF-β/SMAD signaling by protein deubiquitination
por: Zhang, Juan, et al.
Publicado: (2014)

Regulation of TGF-β Superfamily Signaling by SMAD Mono-Ubiquitination
por: Xie, Feng, et al.
Publicado: (2014)

Increased Smad3 and reduced Smad2 levels mediate the functional switch of TGF-β from growth suppressor to growth and metastasis promoter through TMEPAI/PMEPA1 in triple negative breast cancer
por: Singha, Prajjal K., et al.
Publicado: (2019)

MicroRNA-10a/b inhibit TGF-β/Smad-induced renal fibrosis by targeting TGF-β receptor 1 in diabetic kidney disease
por: Li, Jinxiang, et al.
Publicado: (2022)

Baicalin inhibits the TGF-β1/p-Smad3 pathway to suppress epithelial-mesenchymal transition-induced metastasis in breast cancer
por: Liu, Ding-Kuo, et al.
Publicado: (2020)

Inhibition of keloid by (32)P isotope radiotherapy through suppressing TGF-β/Smad signaling pathway
por: Xie, Long, et al.
Publicado: (2023)

Suppression of TGF-β pathway by pirfenidone decreases extracellular matrix deposition in ocular fibroblasts in vitro
por: Stahnke, Thomas, et al.
Publicado: (2017)

miR-425 suppresses EMT and the development of TNBC (triple-negative breast cancer) by targeting the TGF-β 1/SMAD 3 signaling pathway
por: Liu, Yingping, et al.
Publicado: (2018)

SRGN-TGFβ2 regulatory loop confers invasion and metastasis in triple-negative breast cancer
por: Zhang, Z, et al.
Publicado: (2017)

KLF17 empowers TGF-β/Smad signaling by targeting Smad3-dependent pathway to suppress tumor growth and metastasis during cancer progression
por: Ali, A, et al.
Publicado: (2015)

The testis protein ZNF165 is a SMAD3 cofactor that coordinates oncogenic TGFβ signaling in triple-negative breast cancer
por: Gibbs, Zane A, et al.
Publicado: (2020)

DGKZ promotes TGFβ signaling pathway and metastasis in triple-negative breast cancer by suppressing lipid raft-dependent endocytosis of TGFβR2
por: Zhao, Yuanyuan, et al.
Publicado: (2022)

FUBP1 mediates the growth and metastasis through TGFβ/Smad signaling in pancreatic adenocarcinoma
por: Zhang, Yue, et al.
Publicado: (2021)

Pirfenidone alleviates pulmonary fibrosis in vitro and in vivo through regulating Wnt/GSK-3β/β-catenin and TGF-β1/Smad2/3 signaling pathways
por: Lv, Qun, et al.
Publicado: (2020)

KDM6A suppresses hepatocellular carcinoma cell proliferation by negatively regulating the TGF-β/SMAD signaling pathway
por: Li, Yuan, et al.
Publicado: (2020)

Pirfenidone: is it tolerable?
por: Lara, Abigail, et al.
Publicado: (2016)

MicroRNA-133b targets TGFβ receptor I to inhibit TGF-β-induced epithelial-to-mesenchymal transition and metastasis by suppressing the TGF-β/SMAD pathway in breast cancer
por: WANG, SHENGJIE, et al.
Publicado: (2019)

An inhibitory role of NEK6 in TGFβ/Smad signaling pathway
por: Zuo, Jie, et al.
Publicado: (2015)

Aspirin inhibits endometrial fibrosis by suppressing the TGF-β1-Smad2/Smad3 pathway in intrauterine adhesions
por: Zhang, Zihui, et al.
Publicado: (2020)

Cytokines secreted from adipose tissues mediate tumor proliferation and metastasis in triple negative breast cancer
por: Zhang, Kai, et al.
Publicado: (2022)

TGF-β/Smad signaling through DOCK4 facilitates lung adenocarcinoma metastasis
por: Yu, Jia-Ray, et al.
Publicado: (2015)

[Corrigendum] MicroRNA-133b targets TGFβ receptor I to inhibit TGF-β-induced epithelial-to-mesenchymal transition and metastasis by suppressing the TGF-β/SMAD pathway in breast cancer
por: Wang, Shengjie, et al.
Publicado: (2023)

Magnolol Suppresses Pancreatic Cancer Development In Vivo and In Vitro via Negatively Regulating TGF-β/Smad Signaling
por: Chen, Shuo, et al.
Publicado: (2020)

SALL4 activates TGF-β/SMAD signaling pathway to induce EMT and promote gastric cancer metastasis
por: Zhang, Xu, et al.
Publicado: (2018)

Immune infiltration in renal cell carcinoma
por: Zhang, Shichao, et al.
Publicado: (2019)

MicroRNA-302b mitigates renal fibrosis via inhibiting TGF-β/Smad pathway activation
por: Sun, Mengkui, et al.
Publicado: (2021)

A Novel TGFβ Modulator that Uncouples R-Smad/I-Smad-Mediated Negative Feedback from R-Smad/Ligand-Driven Positive Feedback
por: Gu, Wenchao, et al.
Publicado: (2015)

FOXC1-induced LINC01123 acts as a mediator in triple negative breast cancer
por: Zhang, Purong, et al.
Publicado: (2020)

Long non-coding RNA ANRIL promotes the invasion and metastasis of thyroid cancer cells through TGF-β/Smad signaling pathway
por: Zhao, Jian-Jie, et al.
Publicado: (2016)

Biphasic Effect of Pirfenidone on Angiogenesis
por: Gan, Donghao, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_8prpkevf2cjp60vel2st0rutkb