Current understanding of imeglimin action on pancreatic β‐cells: Involvement of mitochondria and endoplasmic reticulum homeostasis

Recent preclinical studies have provided insight on imeglimin's action on pancreatic β‐cells and the mechanisms underlying its clinical benefits. Imeglimin may enhance glucose‐induced insulin secretion (GIIS) and inhibit apoptosis of pancreatic ß‐cells leading to preserved β‐cell mass by mainta...

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Detalles Bibliográficos
Autores principales: Fauzi, Muhammad, Murakami, Takaaki, Yabe, Daisuke, Inagaki, Nobuya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Commentaries
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9889698/
https://www.ncbi.nlm.nih.gov/pubmed/36453164
http://dx.doi.org/10.1111/jdi.13951
Descripción
Sumario:Recent preclinical studies have provided insight on imeglimin's action on pancreatic β‐cells and the mechanisms underlying its clinical benefits. Imeglimin may enhance glucose‐induced insulin secretion (GIIS) and inhibit apoptosis of pancreatic ß‐cells leading to preserved β‐cell mass by maintaining or restoring the functional and structural integrity of the mitochondria and the endoplasmic reticulum homeostasis in pancreatic β‐cells.[Image: see text]

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