Current understanding of imeglimin action on pancreatic β‐cells: Involvement of mitochondria and endoplasmic reticulum homeostasis

Recent preclinical studies have provided insight on imeglimin's action on pancreatic β‐cells and the mechanisms underlying its clinical benefits. Imeglimin may enhance glucose‐induced insulin secretion (GIIS) and inhibit apoptosis of pancreatic ß‐cells leading to preserved β‐cell mass by mainta...

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Detalles Bibliográficos
Autores principales: Fauzi, Muhammad, Murakami, Takaaki, Yabe, Daisuke, Inagaki, Nobuya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Commentaries
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9889698/
https://www.ncbi.nlm.nih.gov/pubmed/36453164
http://dx.doi.org/10.1111/jdi.13951
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author Fauzi, Muhammad
Murakami, Takaaki
Yabe, Daisuke
Inagaki, Nobuya
author_facet Fauzi, Muhammad
Murakami, Takaaki
Yabe, Daisuke
Inagaki, Nobuya
author_sort Fauzi, Muhammad
collection PubMed
description Recent preclinical studies have provided insight on imeglimin's action on pancreatic β‐cells and the mechanisms underlying its clinical benefits. Imeglimin may enhance glucose‐induced insulin secretion (GIIS) and inhibit apoptosis of pancreatic ß‐cells leading to preserved β‐cell mass by maintaining or restoring the functional and structural integrity of the mitochondria and the endoplasmic reticulum homeostasis in pancreatic β‐cells.[Image: see text]
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spelling pubmed-98896982023-02-02 Current understanding of imeglimin action on pancreatic β‐cells: Involvement of mitochondria and endoplasmic reticulum homeostasis Fauzi, Muhammad Murakami, Takaaki Yabe, Daisuke Inagaki, Nobuya J Diabetes Investig Commentaries Recent preclinical studies have provided insight on imeglimin's action on pancreatic β‐cells and the mechanisms underlying its clinical benefits. Imeglimin may enhance glucose‐induced insulin secretion (GIIS) and inhibit apoptosis of pancreatic ß‐cells leading to preserved β‐cell mass by maintaining or restoring the functional and structural integrity of the mitochondria and the endoplasmic reticulum homeostasis in pancreatic β‐cells.[Image: see text] John Wiley and Sons Inc. 2022-12-01 /pmc/articles/PMC9889698/ /pubmed/36453164 http://dx.doi.org/10.1111/jdi.13951 Text en © 2022 The Authors. Journal of Diabetes Investigation published by Asian Association for the Study of Diabetes (AASD) and John Wiley & Sons Australia, Ltd. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Commentaries
Fauzi, Muhammad
Murakami, Takaaki
Yabe, Daisuke
Inagaki, Nobuya
Current understanding of imeglimin action on pancreatic β‐cells: Involvement of mitochondria and endoplasmic reticulum homeostasis
title Current understanding of imeglimin action on pancreatic β‐cells: Involvement of mitochondria and endoplasmic reticulum homeostasis
title_full Current understanding of imeglimin action on pancreatic β‐cells: Involvement of mitochondria and endoplasmic reticulum homeostasis
title_fullStr Current understanding of imeglimin action on pancreatic β‐cells: Involvement of mitochondria and endoplasmic reticulum homeostasis
title_full_unstemmed Current understanding of imeglimin action on pancreatic β‐cells: Involvement of mitochondria and endoplasmic reticulum homeostasis
title_short Current understanding of imeglimin action on pancreatic β‐cells: Involvement of mitochondria and endoplasmic reticulum homeostasis
title_sort current understanding of imeglimin action on pancreatic β‐cells: involvement of mitochondria and endoplasmic reticulum homeostasis
topic Commentaries
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9889698/
https://www.ncbi.nlm.nih.gov/pubmed/36453164
http://dx.doi.org/10.1111/jdi.13951
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