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Serum 25‐hydroxyvitamin D concentrations in dogs with coccidioidomycosis and variables associated with extent of clinically evident disease

BACKGROUND: Clinicopathologic variables predictive of disseminated coccidioidomycosis are known in humans but have not been explored in dogs. Serum 25‐hydroxyvitamin (OH)D correlates with severity of disease of various etiologies in dogs but its role in coccidioidomycosis is unknown. OBJECTIVE: Dete...

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Autores principales: Jaffey, Jared A., Kreisler, Rachael, Shubitz, Lisa F., Backus, Robert C., Hostnik, Eric T., Wycislo, Kathryn L., Monasky, Ross, Schaffer, Magen, Holland, Cyndi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9889719/
https://www.ncbi.nlm.nih.gov/pubmed/36629803
http://dx.doi.org/10.1111/jvim.16629
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author Jaffey, Jared A.
Kreisler, Rachael
Shubitz, Lisa F.
Backus, Robert C.
Hostnik, Eric T.
Wycislo, Kathryn L.
Monasky, Ross
Schaffer, Magen
Holland, Cyndi
author_facet Jaffey, Jared A.
Kreisler, Rachael
Shubitz, Lisa F.
Backus, Robert C.
Hostnik, Eric T.
Wycislo, Kathryn L.
Monasky, Ross
Schaffer, Magen
Holland, Cyndi
author_sort Jaffey, Jared A.
collection PubMed
description BACKGROUND: Clinicopathologic variables predictive of disseminated coccidioidomycosis are known in humans but have not been explored in dogs. Serum 25‐hydroxyvitamin (OH)D correlates with severity of disease of various etiologies in dogs but its role in coccidioidomycosis is unknown. OBJECTIVE: Determine whether serum 25(OH)D concentrations are different in dogs with coccidioidomycosis compared with healthy controls and if clinicopathologic variables are associated with extent of disease. ANIMALS: Thirty‐five dogs with coccidioidomycosis (pulmonary, n = 13; disseminated, n = 15; uncharacterized, n = 7), and 25 healthy control dogs. METHODS: Prospective cohort study. Serum 25(OH)D and C‐reactive protein (CRP) concentrations were measured with modified‐HPLC and a commercial ELISA kit, respectively. RESULTS: There was no difference in 25(OH)D concentrations between dogs with coccidioidomycosis (median, interquartile range [IQR]; 31.9 ng/mL, 23.3‐49.2) and controls (29.5 ng/mL, 25.6‐40.8, P = .73). Serum 25(OH)D concentration was lower in dogs with coccidioidomycosis and IgG titers ≥1:32 than dogs with titers below this cut‐off (P = .02). Dogs with IgG titers ≥1:32 were more likely to have disseminated disease (OR, 7.5; 95% CI: 1.1‐68; P = .03). Serum CRP concentrations were higher in dogs with IgG titers ≥1:16 (median, IQR; 4474.8 ng/mL, 2885.8‐8236.1) than in those below this cut‐off (151.2 ng/mL, 30.4‐2907.3; P = .02). There was a significant inverse association between serum 25(OH)D and CRP at 25(OH)D concentrations ≤33 ng/mL. CONCLUSION AND CLINICAL IMPORTANCE: Serum 25(OH)D concentration was lower for dogs with IgG titers ≥1:32, indicating a potential association between semi‐quantitative titers and 25(OH)D concentrations in dogs with coccidioidomycosis. IgG titers ≥1:32 yielded higher odds of disseminated disease, but was inadequate as a standalone test to determine form of disease.
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spelling pubmed-98897192023-02-02 Serum 25‐hydroxyvitamin D concentrations in dogs with coccidioidomycosis and variables associated with extent of clinically evident disease Jaffey, Jared A. Kreisler, Rachael Shubitz, Lisa F. Backus, Robert C. Hostnik, Eric T. Wycislo, Kathryn L. Monasky, Ross Schaffer, Magen Holland, Cyndi J Vet Intern Med SMALL ANIMAL BACKGROUND: Clinicopathologic variables predictive of disseminated coccidioidomycosis are known in humans but have not been explored in dogs. Serum 25‐hydroxyvitamin (OH)D correlates with severity of disease of various etiologies in dogs but its role in coccidioidomycosis is unknown. OBJECTIVE: Determine whether serum 25(OH)D concentrations are different in dogs with coccidioidomycosis compared with healthy controls and if clinicopathologic variables are associated with extent of disease. ANIMALS: Thirty‐five dogs with coccidioidomycosis (pulmonary, n = 13; disseminated, n = 15; uncharacterized, n = 7), and 25 healthy control dogs. METHODS: Prospective cohort study. Serum 25(OH)D and C‐reactive protein (CRP) concentrations were measured with modified‐HPLC and a commercial ELISA kit, respectively. RESULTS: There was no difference in 25(OH)D concentrations between dogs with coccidioidomycosis (median, interquartile range [IQR]; 31.9 ng/mL, 23.3‐49.2) and controls (29.5 ng/mL, 25.6‐40.8, P = .73). Serum 25(OH)D concentration was lower in dogs with coccidioidomycosis and IgG titers ≥1:32 than dogs with titers below this cut‐off (P = .02). Dogs with IgG titers ≥1:32 were more likely to have disseminated disease (OR, 7.5; 95% CI: 1.1‐68; P = .03). Serum CRP concentrations were higher in dogs with IgG titers ≥1:16 (median, IQR; 4474.8 ng/mL, 2885.8‐8236.1) than in those below this cut‐off (151.2 ng/mL, 30.4‐2907.3; P = .02). There was a significant inverse association between serum 25(OH)D and CRP at 25(OH)D concentrations ≤33 ng/mL. CONCLUSION AND CLINICAL IMPORTANCE: Serum 25(OH)D concentration was lower for dogs with IgG titers ≥1:32, indicating a potential association between semi‐quantitative titers and 25(OH)D concentrations in dogs with coccidioidomycosis. IgG titers ≥1:32 yielded higher odds of disseminated disease, but was inadequate as a standalone test to determine form of disease. John Wiley & Sons, Inc. 2023-01-11 /pmc/articles/PMC9889719/ /pubmed/36629803 http://dx.doi.org/10.1111/jvim.16629 Text en © 2023 The Authors. Journal of Veterinary Internal Medicine published by Wiley Periodicals LLC on behalf of American College of Veterinary Internal Medicine. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle SMALL ANIMAL
Jaffey, Jared A.
Kreisler, Rachael
Shubitz, Lisa F.
Backus, Robert C.
Hostnik, Eric T.
Wycislo, Kathryn L.
Monasky, Ross
Schaffer, Magen
Holland, Cyndi
Serum 25‐hydroxyvitamin D concentrations in dogs with coccidioidomycosis and variables associated with extent of clinically evident disease
title Serum 25‐hydroxyvitamin D concentrations in dogs with coccidioidomycosis and variables associated with extent of clinically evident disease
title_full Serum 25‐hydroxyvitamin D concentrations in dogs with coccidioidomycosis and variables associated with extent of clinically evident disease
title_fullStr Serum 25‐hydroxyvitamin D concentrations in dogs with coccidioidomycosis and variables associated with extent of clinically evident disease
title_full_unstemmed Serum 25‐hydroxyvitamin D concentrations in dogs with coccidioidomycosis and variables associated with extent of clinically evident disease
title_short Serum 25‐hydroxyvitamin D concentrations in dogs with coccidioidomycosis and variables associated with extent of clinically evident disease
title_sort serum 25‐hydroxyvitamin d concentrations in dogs with coccidioidomycosis and variables associated with extent of clinically evident disease
topic SMALL ANIMAL
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9889719/
https://www.ncbi.nlm.nih.gov/pubmed/36629803
http://dx.doi.org/10.1111/jvim.16629
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