A novel antimicrobial peptide M1‐8 targets the lysosomal pathway to inhibit autolysosome formation and promote apoptosis in liver cancer cells

Lysosomes, a central regulator of autophagy, play a critical role in tumour growth. Lysosomal protease cathepsin D can initiate apoptosis when released from lysosomes into the cytosol. In this study, we observed that Musca domestica cecropin (Mdc) 1–8 (M1‐8), a small anti‐tumour peptide derived from...

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Detalles Bibliográficos
Autores principales: Zeng, Jiali, Wang, Jian, Wu, Jibin, Deng, Rui, Zhang, Lun, Chen, Qingru, Wang, Jie, Jin, Xiaobao, Gui, Shuiqing, Xu, Yinghua, Lu, Xuemei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9889723/
https://www.ncbi.nlm.nih.gov/pubmed/36628597
http://dx.doi.org/10.1111/jcmm.17644

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