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Mechanism of hormone and allosteric agonist mediated activation of follicle stimulating hormone receptor

Follicle stimulating hormone (FSH) is an essential glycoprotein hormone for human reproduction, which functions are mediated by a G protein-coupled receptor, FSHR. Aberrant FSH-FSHR signaling causes infertility and ovarian hyperstimulation syndrome. Here we report cryo-EM structures of FSHR in both...

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Detalles Bibliográficos
Autores principales:	Duan, Jia, Xu, Peiyu, Zhang, Huibing, Luan, Xiaodong, Yang, Jiaqi, He, Xinheng, Mao, Chunyou, Shen, Dan-Dan, Ji, Yujie, Cheng, Xi, Jiang, Hualiang, Jiang, Yi, Zhang, Shuyang, Zhang, Yan, Xu, H. Eric
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9889800/ https://www.ncbi.nlm.nih.gov/pubmed/36720854 http://dx.doi.org/10.1038/s41467-023-36170-3

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