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Research progress of hydrogels as delivery systems and scaffolds in the treatment of secondary spinal cord injury

Secondary spinal cord injury (SSCI) is the second stage of spinal cord injury (SCI) and involves vasculature derangement, immune response, inflammatory response, and glial scar formation. Bioactive additives, such as drugs and cells, have been widely used to inhibit the progression of secondary spin...

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Autores principales: Peng, Haichuan, Liu, Yongkang, Xiao, Fengfeng, Zhang, Limei, Li, Wenting, Wang, Binghan, Weng, Zhijian, Liu, Yu, Chen, Gang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9889880/
https://www.ncbi.nlm.nih.gov/pubmed/36741755
http://dx.doi.org/10.3389/fbioe.2023.1111882
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author Peng, Haichuan
Liu, Yongkang
Xiao, Fengfeng
Zhang, Limei
Li, Wenting
Wang, Binghan
Weng, Zhijian
Liu, Yu
Chen, Gang
author_facet Peng, Haichuan
Liu, Yongkang
Xiao, Fengfeng
Zhang, Limei
Li, Wenting
Wang, Binghan
Weng, Zhijian
Liu, Yu
Chen, Gang
author_sort Peng, Haichuan
collection PubMed
description Secondary spinal cord injury (SSCI) is the second stage of spinal cord injury (SCI) and involves vasculature derangement, immune response, inflammatory response, and glial scar formation. Bioactive additives, such as drugs and cells, have been widely used to inhibit the progression of secondary spinal cord injury. However, the delivery and long-term retention of these additives remain a problem to be solved. In recent years, hydrogels have attracted much attention as a popular delivery system for loading cells and drugs for secondary spinal cord injury therapy. After implantation into the site of spinal cord injury, hydrogels can deliver bioactive additives in situ and induce the unidirectional growth of nerve cells as scaffolds. In addition, physical and chemical methods can endow hydrogels with new functions. In this review, we summarize the current state of various hydrogel delivery systems for secondary spinal cord injury treatment. Moreover, functional modifications of these hydrogels for better therapeutic effects are also discussed to provide a comprehensive insight into the application of hydrogels in the treatment of secondary spinal cord injury.
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spelling pubmed-98898802023-02-02 Research progress of hydrogels as delivery systems and scaffolds in the treatment of secondary spinal cord injury Peng, Haichuan Liu, Yongkang Xiao, Fengfeng Zhang, Limei Li, Wenting Wang, Binghan Weng, Zhijian Liu, Yu Chen, Gang Front Bioeng Biotechnol Bioengineering and Biotechnology Secondary spinal cord injury (SSCI) is the second stage of spinal cord injury (SCI) and involves vasculature derangement, immune response, inflammatory response, and glial scar formation. Bioactive additives, such as drugs and cells, have been widely used to inhibit the progression of secondary spinal cord injury. However, the delivery and long-term retention of these additives remain a problem to be solved. In recent years, hydrogels have attracted much attention as a popular delivery system for loading cells and drugs for secondary spinal cord injury therapy. After implantation into the site of spinal cord injury, hydrogels can deliver bioactive additives in situ and induce the unidirectional growth of nerve cells as scaffolds. In addition, physical and chemical methods can endow hydrogels with new functions. In this review, we summarize the current state of various hydrogel delivery systems for secondary spinal cord injury treatment. Moreover, functional modifications of these hydrogels for better therapeutic effects are also discussed to provide a comprehensive insight into the application of hydrogels in the treatment of secondary spinal cord injury. Frontiers Media S.A. 2023-01-18 /pmc/articles/PMC9889880/ /pubmed/36741755 http://dx.doi.org/10.3389/fbioe.2023.1111882 Text en Copyright © 2023 Peng, Liu, Xiao, Zhang, Li, Wang, Weng, Liu and Chen. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Bioengineering and Biotechnology
Peng, Haichuan
Liu, Yongkang
Xiao, Fengfeng
Zhang, Limei
Li, Wenting
Wang, Binghan
Weng, Zhijian
Liu, Yu
Chen, Gang
Research progress of hydrogels as delivery systems and scaffolds in the treatment of secondary spinal cord injury
title Research progress of hydrogels as delivery systems and scaffolds in the treatment of secondary spinal cord injury
title_full Research progress of hydrogels as delivery systems and scaffolds in the treatment of secondary spinal cord injury
title_fullStr Research progress of hydrogels as delivery systems and scaffolds in the treatment of secondary spinal cord injury
title_full_unstemmed Research progress of hydrogels as delivery systems and scaffolds in the treatment of secondary spinal cord injury
title_short Research progress of hydrogels as delivery systems and scaffolds in the treatment of secondary spinal cord injury
title_sort research progress of hydrogels as delivery systems and scaffolds in the treatment of secondary spinal cord injury
topic Bioengineering and Biotechnology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9889880/
https://www.ncbi.nlm.nih.gov/pubmed/36741755
http://dx.doi.org/10.3389/fbioe.2023.1111882
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