Linear ubiquitination induces NEMO phase separation to activate NF-κB signaling

The NF-κB essential modulator NEMO is the core regulatory component of the inhibitor of κB kinase complex, which is a critical checkpoint in canonical NF-κB signaling downstream of innate and adaptive immune receptors. In response to various stimuli, such as TNF or IL-1β, NEMO binds to linear or M1-...

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Detalles Bibliográficos
Autores principales: Goel, Simran, Oliva, Rosario, Jeganathan, Sadasivam, Bader, Verian, Krause, Laura J, Kriegler, Simon, Stender, Isabelle D, Christine, Chadwick W, Nakamura, Ken, Hoffmann, Jan-Erik, Winter, Roland, Tatzelt, Jörg, Winklhofer, Konstanze F
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Life Science Alliance LLC 2023
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9889916/
https://www.ncbi.nlm.nih.gov/pubmed/36720498
http://dx.doi.org/10.26508/lsa.202201607

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