In vivo stabilization of a less toxic asparaginase variant leads to a durable antitumor response in acute leukemia

Asparagine is a non-essential amino acid since it can either be taken up via the diet or synthesized by asparagine synthetase. Acute lymphoblastic leukemia (ALL) cells do not express asparagine synthetase or express it only minimally, which makes them completely dependent on extracellular asparagine...

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Detalles Bibliográficos
Autores principales: Van Trimpont, Maaike, Schalk, Amanda M., De Visser, Yanti, Nguyen, Hien Anh, Reunes, Lindy, Vandemeulebroecke, Katrien, Peeters, Evelien, Su, Ying, Lee, Hyun, Lorenzi, Philip L., Chan, Wai-Kin, Mondelaers, Veerle, De Moerloose, Barbara, Lammens, Tim, Goossens, Steven, Van Vlierberghe, Pieter, Lavie, Arnon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Fondazione Ferrata Storti 2022
Materias:
Article - Acute Lymphoblastic Leukemia
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9890011/
https://www.ncbi.nlm.nih.gov/pubmed/35979719
http://dx.doi.org/10.3324/haematol.2022.281390

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