All-trans retinoic acid works synergistically with the γ-secretase inhibitor crenigacestat to augment BCMA on multiple myeloma and the efficacy of BCMA-CAR T cells

B-cell maturation antigen (BCMA) is the lead antigen for chimeric antigen receptor (CAR) T-cell therapy in multiple myeloma (MM). A challenge is inter- and intra-patient heterogeneity in BCMA expression on MM cells and BCMA downmodulation under therapeutic pressure. Accordingly, there is a desire to...

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Detalles Bibliográficos
Autores principales: García-Guerrero, Estefanía, Rodríguez-Lobato, Luis G., Sierro-Martínez, Belén, Danhof, Sophia, Bates, Stephan, Frenz, Silke, Haertle, Larissa, Götz, Ralph, Sauer, Markus, Rasche, Leo, Kortüm, K. Martin, Pérez-Simón, Jose A., Einsele, Hermann, Hudecek, Michael, Prommersberger, Sabrina R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Fondazione Ferrata Storti 2022
Materias:
Article - Plasma cell disorders
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9890012/
https://www.ncbi.nlm.nih.gov/pubmed/36722406
http://dx.doi.org/10.3324/haematol.2022.281339

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