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Osteoprogenitor SFRP1 prevents exhaustion of hematopoietic stem cells via PP2A-PR72/130-mediated regulation of p300

Remodeling of the bone marrow microenvironment in chronic inflammation and in aging reduces hematopoietic stem cell (HSC) function. To assess the mechanisms of this functional decline of HSC and find strategies to counteract it, we established a model in which the Sfrp1 gene was deleted in Osterix(+...

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Detalles Bibliográficos
Autores principales:	Hettler, Franziska, Schreck, Christina, Marquez, Sandra Romero, Engleitner, Thomas, Vilne, Baiba, Landspersky, Theresa, Weidner, Heike, Hausinger, Renate, Mishra, Ritu, Oellinger, Rupert, Rauner, Martina, Naumann, Ronald, Peschel, Christian, Bassermann, Florian, Rad, Roland, Istvanffy, Rouzanna, Oostendorp, Robert A.J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Fondazione Ferrata Storti 2022
Materias:	Article - Hematopoiesis
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9890018/ https://www.ncbi.nlm.nih.gov/pubmed/35950533 http://dx.doi.org/10.3324/haematol.2022.280760

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