Targeting dual oncogenic machineries driven by TAL1 and PI3K-AKT pathways in T-cell acute lymphoblastic leukemia

T-cell acute lymphoblastic leukemia (T-ALL) is a malignancy of thymic T-cell precursors. Overexpression of oncogenic transcription factor TAL1 is observed in 40-60% of human T-ALL cases, frequently together with activation of the NOTCH1 and PI3K-AKT pathways. In this study, we performed chemical scr...

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Detalles Bibliográficos
Autores principales: Lim, Fang Qi, Chan, Allison Si-Yu, Yokomori, Rui, Huang, Xiao Zi, Theardy, Madelaine Skolastika, Yeoh, Allen Eng Juh, Tan, Shi Hao, Sanda, Takaomi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Fondazione Ferrata Storti 2022
Materias:
Article - Acute Lymphoblastic Leukemia
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9890034/
https://www.ncbi.nlm.nih.gov/pubmed/36073513
http://dx.doi.org/10.3324/haematol.2022.280761

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9890034/
https://www.ncbi.nlm.nih.gov/pubmed/36073513
http://dx.doi.org/10.3324/haematol.2022.280761

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